{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:27:22Z","timestamp":1749454042978,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>There is little evidence of the impact of syncope in implantable cardioverter-defibrillator (ICD) patients in routine community hospital care. This single-centre retrospective study sought to evaluate the incidence and prognostic significance of syncope in consecutive ICD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Data were collected on consecutive patients undergoing first ICD implantation between January 2009 and December 2019. The primary endpoints were the first occurrence of all-cause syncope, all-cause mortality, and all-cause hospitalization. Multivariate Cox proportional hazard models were used to identify risk factors associated with syncope and to analyse the subsequent risk of mortality and hospitalization. 1003 patients (58% primary prevention) were included in the final analysis. During a mean follow-up of 1519 \u00b1 1055 days, 106 (10.6%) experienced syncope, 304 died (30.3%), and 477 (47.5%) were hospitalized for any cause. In an analysis adjusted for baseline variables, the first occurrence of syncope was associated with a significantly increased risk of mortality (HR 2.82, P &amp;lt; 0.001) and the first occurrence of hospitalization (HR 2.46, P = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Syncope in ICD recipients is common and associated with a poor prognosis irrespective of baseline variables and ICD programming. The occurrence of syncope is associated with a significant increase in the risk of mortality and hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euac281","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T01:58:34Z","timestamp":1673661514000},"page":"940-947","source":"Crossref","is-referenced-by-count":1,"title":["Syncope in ICD recipients: a single centre experience"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-7188","authenticated-orcid":false,"given":"Parisha","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karshana","family":"Selvarajah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-7135","authenticated-orcid":false,"given":"Sheena","family":"Gohel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-7360","authenticated-orcid":false,"given":"Baldeep S","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-6297","authenticated-orcid":false,"given":"Antonio","family":"Cannat\u00e0","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London , James Black Centre, London SE5 9NU , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-5964","authenticated-orcid":false,"given":"Daniel I","family":"Bromage","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London , James Black Centre, London SE5 9NU , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-9602","authenticated-orcid":false,"given":"Theresa","family":"McDonagh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London , James Black Centre, London SE5 9NU , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-7504","authenticated-orcid":false,"given":"Francis","family":"Murgatroyd","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King's College Hospital NHS Foundation Trust , Denmark Hill, London SE5 9RS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,14]]},"reference":[{"key":"2023033021231887800_","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1161\/01.CIR.0000018125.31973.87","article-title":"Mechanism of syncope in patients with heart disease and negative electrophysiologic test","volume":"105","author":"Menozi","year":"2002","journal-title":"Circulation"},{"key":"2023033021231887800_","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/europace\/euab232","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy.","volume":"24","author":"Glikson","year":"2022","journal-title":"Europace"},{"key":"2023033021231887800_","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0002-9343(95)00052-6","article-title":"Is syncope a risk factor for poor outcomes? 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