{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:00:12Z","timestamp":1776445212613,"version":"3.51.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Maurice Kahn Foundation via the Mayo- Sheba Collaboration Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Intraoperative defibrillation testing (DT) during implant or replacement of implantable cardioverter-defibrillators (ICDs) has been a matter of debate for many years. This debate was put to rest by the Simple and Nordic ICD trials, and the practice of testing during new implantations has essentially been almost abandoned. Old registries demonstrated an increased incidence of significant findings in DT during replacements. The aim of the present study was to evaluate frequency of significant findings and safety of DT in subjects undergoing device replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A prospective observational multi-centre study included consecutive patients undergoing ICD generator replacement. The primary outcome was a failure to terminate induced ventricular fibrillation (VF) with a single shock 10 J below the maximal capacity of the device. Secondary outcomes included complications of DT. Patients were followed-up at 1- and 6-months post-procedure. A total of 92 patients were eligible, and consented to the study, of which 84 underwent DT during battery replacement. The median age was 68 years and 79.8% were males. Induction of VF was successful in 84 patients as was a successful conversion on the first attempt in all. There were no procedure-related complications. During follow up one patient had two appropriate ICD shock events. In four patients, ICD programming was changed. None suffered inappropriate shock. There was no evidence of lead malfunction. Two deaths occurred, none of which was related to arrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study found DT was not associated with complications in patients undergoing ICD generator replacement but produced no clinically important information.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euac282","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T20:39:41Z","timestamp":1673642381000},"page":"956-960","source":"Crossref","is-referenced-by-count":2,"title":["Outcome and safety of intraoperative defibrillation testing during device replacement: the Simpler trial"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-4101","authenticated-orcid":false,"given":"Anat","family":"Milman","sequence":"first","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center , Tel Hashomer, 52621 Ramat Gan , Israel"},{"name":"Sackler School of Medicine, Tel Aviv University , P.O. Box 39040, Tel Aviv 6997801 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Nof","sequence":"additional","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center , Tel Hashomer, 52621 Ramat Gan , Israel"},{"name":"Sackler School of Medicine, Tel Aviv University , P.O. Box 39040, Tel Aviv 6997801 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-9947","authenticated-orcid":false,"given":"Moshe","family":"Rav Acha","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center Shaare Zedek Medical Center and Hebrew University Faculty of Medicine , PO Box 3235, Jerusalem 9103102 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-8298","authenticated-orcid":false,"given":"Roy","family":"Beinart","sequence":"additional","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center , Tel Hashomer, 52621 Ramat Gan , Israel"},{"name":"Sackler School of Medicine, Tel Aviv University , P.O. Box 39040, Tel Aviv 6997801 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-289X","authenticated-orcid":false,"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Ave , Box 653 Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-0723","authenticated-orcid":false,"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest , Hat\u00e1r\u0151r street 18, Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-2820","authenticated-orcid":false,"given":"Ehud","family":"Regev","sequence":"additional","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center , Tel Hashomer, 52621 Ramat Gan , Israel"},{"name":"Sackler School of Medicine, Tel Aviv University , P.O. Box 39040, Tel Aviv 6997801 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8584","authenticated-orcid":false,"given":"Mauro","family":"Biffi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Policlinico S. Orsola-Malpighi, University of Bologna , Via Giuseppe Massarenti, 9, 40138 Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-9464","authenticated-orcid":false,"given":"Yong-Mei","family":"Cha","sequence":"additional","affiliation":[{"name":"Mayo Clinic, 200 First St. SW Rochester , Minnesota 55905 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3358-3797","authenticated-orcid":false,"given":"Tal","family":"Ovdat","sequence":"additional","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center , Tel Hashomer, 52621 Ramat Gan , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[{"name":"Leviev Heart Institute, The Chaim Sheba Medical Center , Tel Hashomer, 52621 Ramat Gan , Israel"},{"name":"Sackler School of Medicine, Tel Aviv University , P.O. Box 39040, Tel Aviv 6997801 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Glikson","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center Shaare Zedek Medical Center and Hebrew University Faculty of Medicine , PO Box 3235, Jerusalem 9103102 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"2023033021231972200_","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1093\/eurheartj\/ehv292","article-title":"Intra-operative defibrillation testing and clinical shock efficacy in patients with implantable cardioverter-defibrillators: the NORDIC ICD randomized clinical trial","volume":"36","author":"B\u00e4nsch","year":"2015","journal-title":"Eur Heart J"},{"key":"2023033021231972200_","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(14)61903-6","article-title":"Cardioverter defibrillator 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