{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:16:10Z","timestamp":1790162170181,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to compare procedural efficacy and safety, including 1-year freedom from AF recurrence, between the novel cryoballoon system PolarX (Boston Scientific) and the Arctic Front Advance Pro (AFA-Pro) (Medtronic), in patients with paroxysmal AF undergoing PVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This multicentre prospective observational study included 267 consecutive patients undergoing a first cryoablation procedure for paroxysmal AF (137 PolarX, 130 AFA-Pro). Kaplan-Meier curves with the log-rank test was used to compare the 1-year freedom from AF recurrence between both groups. Multivariate Cox model was performed to evaluate whether the type of procedure (PolarX vs. AFA-Pro) had an impact on the occurrence of AF recurrences after adjustment on potentially confounding factors. The PolarX reaches lower temperatures than the AFA-Pro (LSPV 52 \u00b1 5, vs. 59 \u00b1 6; LIPV 49 \u00b1 6 vs. 56 \u00b1 6; right superior pulmonary vein: 49 \u00b1 6 vs. 57 \u00b1 7; right inferior pulmonary vein: 52 \u00b1 6 vs. 59 \u00b1 6; P &amp;lt; 0.0001). A higher rate of transient phrenic nerve palsy was found in patients treated with the PolarX system (15% vs. 7%, P = 0.05). After a mean follow-up of 15 \u00b1 5 months, 20 patients (15%) had recurrences in AFA-Pro group and 27 patients (19%) in PolarX group (P = 0.35). Based on survival analysis, no significant difference was observed between both groups with a 12-month free of recurrence survival of 91.2% (85.1\u201395.4%) vs. 83.7% (76.0%\u201389.1%) (log-rank test P = 0.11). In multivariate Cox model hazard ratio of recurrence for PolarX vs. AFA-Pro was not significant [HR = 1.6 (0.9\u20132.8), P = 0.12].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PolarX and AFA-Pro have comparable efficacy and safety profiles for pulmonary veins isolation in paroxysmal atrial fibrillation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euad005","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:16:59Z","timestamp":1674645419000},"page":"873-879","source":"Crossref","is-referenced-by-count":51,"title":["Outcomes after cryoballoon ablation of paroxysmal atrial fibrillation with the PolarX or the Arctic Front Advance Pro: a prospective multicentre experience"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-7552","authenticated-orcid":false,"given":"Nikita","family":"Tanese","sequence":"first","affiliation":[{"name":"Heart Rhythm Department, Clinique Pasteur , 45 Avenue de Lombez, 31076 Toulouse Cedex 3 , France"},{"name":"Cardiology Department , San Raffaele Hospital, Via Olgettina 60, 20132 Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-1661","authenticated-orcid":false,"given":"Alexandre","family":"Almorad","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universiteit Ziekenhuis, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 101, 1090 Jette Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-1511","authenticated-orcid":false,"given":"Luigi","family":"Pannone","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universiteit Ziekenhuis, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 101, 1090 Jette Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-4278","authenticated-orcid":false,"given":"Pascal","family":"Defaye","sequence":"additional","affiliation":[{"name":"Arrythmia Departement University Hospital of Grenoble-Alpes and Grenoble Alpes University , Boulevard de la Chantourne, 38700 La Tronche , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-305X","authenticated-orcid":false,"given":"Sophie","family":"Jacob","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Institute of Radiation Protection and Nuclear Safety (IRSN) , 31 Av. de la Division Leclerc, 92260 Fontenay-aux-Roses , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-2443","authenticated-orcid":false,"given":"Mouna Ben","family":"Kilani","sequence":"additional","affiliation":[{"name":"Arrythmia Departement University Hospital of Grenoble-Alpes and Grenoble Alpes University , Boulevard de la Chantourne, 38700 La Tronche , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-1345","authenticated-orcid":false,"given":"Gianbattista","family":"Chierchia","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universiteit Ziekenhuis, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 101, 1090 Jette Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-5089","authenticated-orcid":false,"given":"Sandrine","family":"Venier","sequence":"additional","affiliation":[{"name":"Arrythmia Departement University Hospital of Grenoble-Alpes and Grenoble Alpes University , Boulevard de la Chantourne, 38700 La Tronche , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christ\u00e8le","family":"Cardin","sequence":"additional","affiliation":[{"name":"Heart Rhythm Department, Clinique Pasteur , 45 Avenue de Lombez, 31076 Toulouse Cedex 3 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Jacon","sequence":"additional","affiliation":[{"name":"Arrythmia Departement University Hospital of Grenoble-Alpes and Grenoble Alpes University , Boulevard de la Chantourne, 38700 La Tronche , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Combes","sequence":"additional","affiliation":[{"name":"Heart Rhythm Department, Clinique Pasteur , 45 Avenue de Lombez, 31076 Toulouse Cedex 3 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-4318","authenticated-orcid":false,"given":"Elodie","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Arrythmia Departement University Hospital of Grenoble-Alpes and Grenoble Alpes University , Boulevard de la Chantourne, 38700 La Tronche , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1671-1977","authenticated-orcid":false,"given":"Roberto","family":"Men\u00e8","sequence":"additional","affiliation":[{"name":"Heart Rhythm Department, Clinique Pasteur , 45 Avenue de Lombez, 31076 Toulouse Cedex 3 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-0760","authenticated-orcid":false,"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and 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