{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:59:06Z","timestamp":1769083146023,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"crossref","award":["12-1352259"],"award-info":[{"award-number":["12-1352259"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Research Foundation for the Capital Region of Denmark"},{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"crossref","award":["11-04-R83-A3363-22625"],"award-info":[{"award-number":["11-04-R83-A3363-22625"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Aalborg University Talent Management Program"},{"DOI":"10.13039\/100007460","name":"Arvid Nilssons Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008276","name":"Skibsreder Per Henriksen, R og Hustrus Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008276","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union\u2019s Horizon 2020 programme","award":["847770"],"award-info":[{"award-number":["847770"]}]},{"DOI":"10.13039\/501100008269","name":"L\u00e6ge Sophus Carl Emil Friis og hustru Olga Doris Friis\u2019 Legat","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medtronic"},{"name":"European Union\u2019s Horizon 2020 programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Insights into subclinical atrial fibrillation (AF) development are warranted to inform the strategies of screening and subsequent clinical management upon AF detection. Hence, this study sought to characterize the onset and progression of subclinical AF with respect to 12-lead electrocardiogram (ECG) parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We included AF-na\u00efve individuals aged 70\u201390 years with additional stroke risk factors who underwent implantable loop recorder (ILR) monitoring in the LOOP Study. Using data from daily ILR recordings and the computerized analysis of baseline ECG, we studied empirically selected ECG parameters for AF detection (\u22656\u2005min), cumulative AF burden, long-lasting AF (\u226524\u2005h), and AF progression. Of 1370 individuals included, 419 (30.6%) developed AF during follow-up, with a mean cumulative AF burden of 1.5% [95% CI: 1.2\u20131.8]. Several P-wave-related and ventricular ECG parameters were associated with new-onset AF and with cumulative AF burden in AF patients. P-wave duration (PWD), P-wave terminal force in Lead V1, and interatrial block (IAB) further demonstrated significant associations with long-lasting AF. Among AF patients, we observed an overall reduction in cumulative AF burden over time (IRR 0.70 [95% CI: 0.51\u20130.96]), whereas IAB was related to an increased risk of progression to AF \u226524\u2005h (HR 1.86 [95% CI: 1.02\u20133.39]). Further spline analysis also revealed longer PWD to be associated with this progression in AF duration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We identified several ECG parameters associated with new-onset subclinical AF detected by ILR. Especially PWD and IAB were robustly related to the onset and the burden of AF as well as progression over time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad014","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:57:57Z","timestamp":1681779477000},"source":"Crossref","is-referenced-by-count":12,"title":["Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-3125","authenticated-orcid":false,"given":"Lucas Yixi","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Inge Lehmanns Vej 7, 2100 Copenhagen , Denmark"},{"name":"Department of Cardiology, Zealand University Hospital Roskilde , 4000 Roskilde , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-0857","authenticated-orcid":false,"given":"S\u00f8ren Z\u00f6ga","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Inge Lehmanns Vej 7, 2100 Copenhagen , Denmark"},{"name":"Department of Cardiology, Bispebjerg Hospital, Copenhagen University Hospital , 2400 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8385-587X","authenticated-orcid":false,"given":"S\u00f8ren","family":"H\u00f8jberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bispebjerg Hospital, Copenhagen University Hospital , 2400 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-7333","authenticated-orcid":false,"given":"Derk W","family":"Krieger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mediclinic City Hospital , Dubai , United Arabic Emirates"},{"name":"Department of Neuroscience, Mohammed Bin Rashid University of Medicine and Health Science , Dubai , United Arabic Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9650-9781","authenticated-orcid":false,"given":"Claus","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University , 9220 Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten S","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Inge Lehmanns Vej 7, 2100 Copenhagen , Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-2852","authenticated-orcid":false,"given":"Jonas Bille","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Inge Lehmanns Vej 7, 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-6887","authenticated-orcid":false,"given":"Axel","family":"Brandes","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , 5000 Odense C , Denmark"},{"name":"Department of Cardiology, Odense University Hospital , 5000 Odense , Denmark"},{"name":"Department of Cardiology, University Hospital of Southern Denmark Esbjerg , 6700 Esbjerg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Inge Lehmanns Vej 7, 2100 Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5584-8445","authenticated-orcid":false,"given":"Ketil J\u00f8rgen","family":"Haugan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital Roskilde , 4000 Roskilde , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-8515","authenticated-orcid":false,"given":"Jesper Hastrup","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Inge Lehmanns Vej 7, 2100 Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"2023053007594682500_euad014-B1","article-title":"Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. 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