{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:53:51Z","timestamp":1771671231128,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aimed to examine the clinical benefits of targeted ablation of all Premature ventricular complex (PVC) morphologies vs. predominant PVC only.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 171 consecutive patients with reduced left ventricular ejection fraction (LVEF) and \u22652 PVC morphology with high burden (&amp;gt;10%\/day) undergoing their first ablation procedure were included in the analysis. At the initial procedure, prevalent PVC alone was ablated in the majority. However, at the redo, all PVC morphologies were targeted for ablation. : At the first procedure, 152 (89%) patients received ablation of the dominant PVC only. In the remaining 19 (11%) patients, all PVC morphologies were ablated. At two years, high PVC burden was detected in 89 (52%) patients. Repeat procedure was performed in 78 of 89, where all PVC morphologies were ablated. At 5 years after the repeat procedure, 71 (91%) had PVC burden of &amp;lt;5% [3.8 \u00b1 1.1% vs. 15.4 \u00b1 4.3% in successful vs. failed subjects (P &amp;lt; 0.001)]. In patients with low PVC burden after the initial procedure, LVEF improved from 37.5% to 41.6% [mean difference (MD): 3.39 \u00b1 2.9%, P &amp;lt; 0.001], whereas a reduction in LVEF from 39.8% to 34.5% (MD: 6.45 \u00b1 4.7%, P &amp;lt; 0.001) was recorded in patients with high PVC burden. One year after the repeat procedure, LVEF improved from 36.2% to 41.7% (MD: 5.5 \u00b1 4.3%, P &amp;lt; 0.001) in patients with successful ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this observational series, ablation of all PVC morphologies was associated with significantly lower PVC burden and improvement of LVEF at long-term follow-up, compared with ablation of the dominant morphology only.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad038","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T22:25:23Z","timestamp":1679437523000},"source":"Crossref","is-referenced-by-count":12,"title":["Best ablation strategy in patients with premature ventricular contractions with multiple morphology: a single-centre experience"],"prefix":"10.1093","volume":"25","author":[{"given":"Sanghamitra","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":false,"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"},{"name":"Department of Electrophysiology, Albert Einstein College of Medicine , 111 East 210th street, Bronx, NY 10467 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasant","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2648-590X","authenticated-orcid":false,"given":"Sai Shishir","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-7207","authenticated-orcid":false,"given":"Carola","family":"Gianni","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3462","authenticated-orcid":false,"given":"Domenico G","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-5730","authenticated-orcid":false,"given":"Karim K","family":"Baho","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5066-1550","authenticated-orcid":false,"given":"Trevor","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-8254","authenticated-orcid":false,"given":"Angel","family":"Mayedo","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-8273","authenticated-orcid":false,"given":"Bryan","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Al-Ahmad","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4924-7066","authenticated-orcid":false,"given":"Mohamed","family":"Bassiouny","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald Joseph","family":"Gallinghouse","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-2941","authenticated-orcid":false,"given":"Rodney","family":"Horton","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-0728","authenticated-orcid":false,"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center , TCAI: 1015 east 32nd street, suite 408, Austin, TX-78705 , USA"},{"name":"Interventional Electrophysiology , Scripps Clinic, 3811 Valley Centre Dr., SD, CA 92130 , USA"},{"name":"Metro Health Medical Center , 2500 MetroHealth Drive, Cleveland, OH 44109 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"2023053008040110000_euad038-B1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cpcardiol.2015.03.002","article-title":"Premature ventricular complexes and premature ventricular Complex induced 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