{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:32:56Z","timestamp":1780713176621,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The optimal anticoagulation regimen in patients with end-stage kidney disease (ESKD) undergoing atrial fibrillation (AF) catheter ablation is unknown. We sought to describe the real-world practice of peri-procedural anticoagulation management in patients with ESKD undergoing AF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients with ESKD on haemodialysis undergoing catheter ablation for AF in 12 referral centres in Japan were included. The international normalized ratio (INR) before and 1 and 3 months after ablation was collected. Peri-procedural major haemorrhagic events as defined by the International Society on Thrombosis and Haemostasis, as well as thromboembolic events, were adjudicated. A total of 347 procedures in 307 patients (67 \u00b19 years, 40% female) were included. Overall, INR values were grossly subtherapeutic [1.58 (interquartile range: 1.20\u20132.00) before ablation, 1.54 (1.22\u20132.02) at 1 month, and 1.22 (1.01\u20131.71) at 3 months]. Thirty-five patients (10%) suffered major complications, the majority of which was major bleeding (19 patients; 5.4%), including 11 cardiac tamponade (3.2%). There were two peri-procedural deaths (0.6%), both related to bleeding events. A pre-procedural INR value of 2.0 or higher was the only independent predictor of major bleeding [odds ratio, 3.3 (1.2\u20138.7), P = 0.018]. No cerebral or systemic thromboembolism occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite most patients with ESKD undergoing AF ablation showing undertreatment with warfarin, major bleeding events are common while thromboembolic events are rare.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euad056","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T13:59:15Z","timestamp":1678370355000},"page":"1400-1407","source":"Crossref","is-referenced-by-count":9,"title":["Peri-procedural anticoagulation in patients with end-stage kidney disease undergoing atrial fibrillation ablation: results from the multicentre end-stage kidney disease\u2013atrial fibrillation ablation registry"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-7126","authenticated-orcid":false,"given":"Tasuku","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University , Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-0934","authenticated-orcid":false,"given":"Shinsuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University , Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-4759","authenticated-orcid":false,"given":"Yasuaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yokosuka Kyosai Hospital , Yonegahama-dori 1-16, Yokosuka-shi, Kanagawa 238-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-3749","authenticated-orcid":false,"given":"Toshikazu","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japanese Red Cross Saitama Hospital , Shintoshin 1-5, Chuo-ku, Saiatama-shi, Saitama 330-8553 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-3127","authenticated-orcid":false,"given":"Tadanori","family":"Nakata","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Tsuchiura Kyodo Hospital , Otsuno 4-1-1, Tsuchiura-shi, Ibaraki 300-0028 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-6617","authenticated-orcid":false,"given":"Akira","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kameda Medical Center , Higashicho 929, Kamogawa-shi, Chiba 296-8602 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-4881","authenticated-orcid":false,"given":"Daisetsu","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Fukui Hospital , Shimoaizuki 2303, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui 910-1193 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-4614","authenticated-orcid":false,"given":"Hirofumi","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japanese Red Cross Yokohama City Bay Hospital , Shinyamashita 3-12-1, Naka-ku, Yokohama-shi, Kanagawa 231-8682 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-3327","authenticated-orcid":false,"given":"Yuta","family":"Taomoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Musashino Red Cross Hospital , Sakaiminami-cho 1-26-1, Musashino-shi, Tokyo 180-8610 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-4422","authenticated-orcid":false,"given":"Tomoki","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Musashino Red Cross Hospital , Sakaiminami-cho 1-26-1, Musashino-shi, Tokyo 180-8610 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-2355","authenticated-orcid":false,"given":"Rintaro","family":"Hojo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Metropolitan Hiroo Hospital , Ebisu 2-34-10, Shibuya-ku, Tokyo 150-0013 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Heart Center, Tokyo Yamate Medical Center , Hyakunin-cho 3-22-1, Shinjuku-ku, Tokyo 169-0073 , 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