{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:11:21Z","timestamp":1777587081951,"version":"3.51.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Abbott. St. Jude Medical"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In bradycardia patients treated with dual-chamber pacing, we aimed to evaluate whether pacing with atrioventricular (AV) delay management [AV hysteresis (AVH)], compared with standard pacing with fixed AV delays, reduces unnecessary ventricular pacing percentage (VPP) and is associated with better clinical outcomes. Main study endpoints were the incidence of heart failure hospitalizations (HFH), persistent atrial fibrillation (AF), and cardiac death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Data from two identical prospective observational studies, BRADYCARE I in the USA and BRADYCARE II in Europe, Africa, and Asia, were pooled. Overall, 2592 patients (75 \u00b1 10 years, 45.1% female, 50% with AVH) had complete clinical and device data at 1-year follow-up and were analysed. Primary pacing indication was sinus node disease (SND) in 1177 (45.4%), AV block (AVB) in 974 (37.6%), and other indications in 441 (17.0%) patients. Pacing with AVH, compared with standard pacing, was associated with a lower 1-year incidence of HFH [1.3% vs. 3.1%, relative risk reduction (RRR) 57.5%, P = 0.002] and of persistent AF (5.3% vs. 7.7%, RRR = 31.1%, P = 0.028). Cardiac mortality was not different between groups (1.0% vs. 1.4%, RRR = 27.8%, P = 0.366). Pacing with AVH, compared with standard pacing, was associated with a lower (P &amp;lt; 0.001) median VPP in all patients (7% vs. 75%), in SND (3% vs. 44%), in AVB (25% vs. 98%), and in patients with other pacing indications (3% vs. 47%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cardiac pacing with AV delay management via AVH is associated with reduced 1-year incidence of HFH and persistent AF, most likely due to a reduction in VPP compared to standard pacing.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad065","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T22:34:26Z","timestamp":1679438066000},"source":"Crossref","is-referenced-by-count":15,"title":["Avoiding unnecessary ventricular pacing is associated with reduced incidence of heart failure hospitalizations and persistent atrial fibrillation in pacemaker patients"],"prefix":"10.1093","volume":"25","author":[{"given":"Martin","family":"Arnold","sequence":"first","affiliation":[{"name":"Cardiology Department, Friedrich-Alexander-Universit\u00e4t , Erlangen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2197-6956","authenticated-orcid":false,"given":"Mark","family":"Richards","sequence":"additional","affiliation":[{"name":"Cardiology Department, Yakima Heart and Vascular , Yakima, WA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-5572","authenticated-orcid":false,"given":"Antonio","family":"D\u2019Onofrio","sequence":"additional","affiliation":[{"name":"Cardiology Department, UOSD di Elettrofisiologia, Studio e Terapia delle Aritmie A.O.R.N. \u2018Ospedali dei Colli\u2019 Osp Monaldi , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Faulknier","sequence":"additional","affiliation":[{"name":"Cardiology, West Virginia University , Vero Beach, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-7125","authenticated-orcid":false,"given":"Michele","family":"Gulizia","sequence":"additional","affiliation":[{"name":"Cardiology Department, Azienda Ospedaliera Garibaldi Nesima , Catania , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Thakur","sequence":"additional","affiliation":[{"name":"Cardiology Department, Thoracic Cardio Healthcare Foundation , Lansing, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-4721","authenticated-orcid":false,"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Cardiology Department, Osaka University Hospital , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Biostatistics, Abbott , Sylmar, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Pollastrelli","sequence":"additional","affiliation":[{"name":"Medical Affairs, Abbott , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-8745","authenticated-orcid":false,"given":"Andrea","family":"Grammatico","sequence":"additional","affiliation":[{"name":"Medical Affairs, Abbott , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-6993","authenticated-orcid":false,"given":"Angelo","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Clinical Electrophysiology Unit, Cardiocentro Ticino Institute , Lugano , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4815","authenticated-orcid":false,"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena University Hospital , Via del Pozzo, 71, Modena 41124 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"2023053008420441100_euad065-B1","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1161\/01.CIR.0000072769.17295.B1","article-title":"Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node 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