{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:25:21Z","timestamp":1789791921662,"version":"4.0.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Ablation of outflow tract ventricular arrhythmias may be limited by a deep intramural location of the arrhythmogenic source. This study evaluates the acute and long-term outcomes of patients undergoing ablation of intramural outflow tract premature ventricular complexes (PVCs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This multicenter series included patients with structurally normal heart or nonischemic cardiomyopathy and intramural outflow tract PVCs defined by: (a) \u2265 2 of the following criteria: (1) earliest endocardial or epicardial activation &amp;lt; 20ms pre-QRS; (2) Similar activation in different chambers; (3) no\/transient PVC suppression with ablation at earliest endocardial\/epicardial site; or (b) earliest ventricular activation recorded in a septal coronary vein. Ninety-two patients were included, with a mean PVC burden of 21.5\u00b110.9%. Twenty-six patients had had previous ablations. All PVCs had inferior axis, with LBBB pattern in 68%. In 29 patients (32%) direct mapping of the intramural septum was performed using an insulated wire or multielectrode catheter, and in 13 of these cases the earliest activation was recorded within a septal vein. Most patients required special ablation techniques (one or more), including sequential unipolar ablation in 73%, low-ionic irrigation in 26%, bipolar ablation in 15% and ethanol ablation in 1%. Acute PVC suppression was achieved in 75% of patients. Following the procedure, the PVC burden was reduced to 5.8\u00b18.4%. The mean follow-up was 15\u00b114 months and 16 patients underwent a repeat ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Ablation of intramural PVCs is challenging; acute arrhythmia elimination is achieved in 3\/4 patients, and non-conventional approaches are often necessary for success.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad100","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T12:26:21Z","timestamp":1682425581000},"source":"Crossref","is-referenced-by-count":43,"title":["Catheter ablation of intramural outflow tract premature ventricular complexes: a multicentre study"],"prefix":"10.1093","volume":"25","author":[{"given":"Matthew","family":"Hanson","sequence":"first","affiliation":[{"name":"Division of Cardiology, Queen\u2019s University , 76 Stuart Street, Kingston, Ontario K7L 2V7 , 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