{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:41:52Z","timestamp":1784119312334,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology"},{"name":"MOST","award":["110-2134- B-002-234"],"award-info":[{"award-number":["110-2134- B-002-234"]}]},{"DOI":"10.13039\/501100022294","name":"National Taiwan University Hospital Yunlin Branch","doi-asserted-by":"crossref","award":["NTUHYL110.S012"],"award-info":[{"award-number":["NTUHYL110.S012"]}],"id":[{"id":"10.13039\/501100022294","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100022294","name":"National Taiwan University Hospital Yunlin Branch","doi-asserted-by":"crossref","award":["NTUHYL 111.S014"],"award-info":[{"award-number":["NTUHYL 111.S014"]}],"id":[{"id":"10.13039\/501100022294","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) is one of the major causes of ischaemic stroke. In addition to clinical risk evaluated by the CHA2DS2-VASC score, the impact of genetic factors on the risk of AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with thromboembolic stroke risk in our AF patients by genome-wide approach. Among them, the gasdermin D (GSDMD) gene was related to inflammation. We aimed to test whether GSDMD deletion was associated with AF-related stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 400 patients with documented non-familial AF were selected, of which 100 patients were diagnosed with ischaemic stroke. The baseline characteristics of age, sex, valvular heart disease, coronary artery disease, heart failure, and CHA2DS2-VASc scores were not statistically different between cases and controls. We found that individuals who carried GSDMD homozygous deletion genotype had a higher risk for ischaemic stroke (odds ratio 2.195; 95% confidence interval, 1.24\u20133.90; P = 0.007), even adjusted by CHA2DS2-VASc scores. We also validated the association of GSDMD with AF stroke in a large Caucasian population (UK Biobank).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We found a link between the homozygous deletion of the GSDMD gene and an increased risk of stroke in patients with AF. This may implicate the use of therapy targeting GSDMD in the prevention of ischaemic stroke for AF patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad103","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T12:43:28Z","timestamp":1682081008000},"source":"Crossref","is-referenced-by-count":3,"title":["Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-2486","authenticated-orcid":false,"given":"Pang-Shuo","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University , Taipei , Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital No. 7, Chung-Shan South Road, Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , No.7, Zhongshan S. Rd., Zhongzheng District, Taipei City 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-5551","authenticated-orcid":false,"given":"Jen-Fang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital No. 7, Chung-Shan South Road, Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , No.7, Zhongshan S. Rd., Zhongzheng District, Taipei City 10002 , Taiwan"},{"name":"Division of Multidisciplinary medicine, Department of Internal Medicine, National Taiwan University Hospital , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4301-5036","authenticated-orcid":false,"given":"Guan-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-0096","authenticated-orcid":false,"given":"Eric Y","family":"Chuang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei , Taiwan"},{"name":"Bioinformatics and Biostatistics Core, Centers of Genomic and Precision Medicine, National Taiwan University , Taipei , Taiwan"},{"name":"Research and Development Center for Medical Devices, National Taiwan University , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-6083","authenticated-orcid":false,"given":"Jien-Jiun","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8282-485X","authenticated-orcid":false,"given":"Fu-Chun","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3867-150X","authenticated-orcid":false,"given":"Cho-Kai","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital No. 7, Chung-Shan South Road, Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , No.7, Zhongshan S. Rd., Zhongzheng District, Taipei City 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chih","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital No. 7, Chung-Shan South Road, Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , No.7, Zhongshan S. Rd., Zhongzheng District, Taipei City 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-0455","authenticated-orcid":false,"given":"Juey-Jen","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital No. 7, Chung-Shan South Road, Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , No.7, Zhongshan S. Rd., Zhongzheng District, Taipei City 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-8665","authenticated-orcid":false,"given":"Chia-Ti","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital No. 7, Chung-Shan South Road, Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , No.7, Zhongshan S. Rd., Zhongzheng District, Taipei City 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,21]]},"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/5\/euad103\/50487598\/euad103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/5\/euad103\/50487598\/euad103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T15:23:14Z","timestamp":1685460194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euad103\/7135529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,19]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euad103","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,4,21]]},"article-number":"euad103"}}