{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:40Z","timestamp":1787008780364,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["31634"],"award-info":[{"award-number":["31634"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"name":"John og Birth Meyer Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Reduced psychological health is associated with adverse patient outcomes and higher mortality. We aimed to examine if a Brugada syndrome (BrS) diagnosis and symptomatic disease presentation were associated with an increased risk of new-onset depression or anxiety and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>All Danish patients diagnosed with BrS (2006\u20132018) with no history of psychiatric disease and available for \u22656 months follow-up were identified using nationwide registries and followed for up to 5 years after diagnosis. The development of clinical depression or anxiety was evaluated using the prescription of medication and diagnosis codes. Factors associated with developing new-onset depression or anxiety were determined using a multivariate Cox proportional hazards regression model. Disease manifestation was categorized as symptomatic (aborted cardiac arrest, ventricular tachycardia, or syncope) or asymptomatic\/unspecified at diagnosis. A total of 223 patients with BrS and no history of psychiatric disease were identified (72.6% male, median age at diagnosis 46 years, 45.3% symptomatic). Of these, 15.7% (35\/223) developed new-onset depression or anxiety after BrS diagnosis (median follow-up 5.0 years). A greater proportion of symptomatic patients developed new-onset depression or anxiety compared with asymptomatic patients [21\/101 (20.8%) and 14\/122 (11.5%), respectively, P = 0.08]. Symptomatic disease presentation (HR 3.43, 1.46\u20138.05) and older age (lower vs. upper tertile: HR 4.41, 1.42\u201313.63) were significantly associated with new-onset depression or anxiety. All-cause mortality in this group of patients treated according to guidelines was low (n = 4, 1.8%); however, 3\/4 developed depression or anxiety before death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately, one-sixth of patients with BrS developed new-onset depression or anxiety following a diagnosis of BrS. Symptomatic BrS disease manifestation was significantly associated with new-onset depression or anxiety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad112","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T12:12:12Z","timestamp":1683029532000},"source":"Crossref","is-referenced-by-count":16,"title":["Severity of Brugada syndrome disease manifestation and risk of new-onset depression or anxiety: a Danish nationwide study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-9637","authenticated-orcid":false,"given":"Camilla H B","family":"Jespersen","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-9434","authenticated-orcid":false,"given":"Johanna","family":"Kr\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1962-2294","authenticated-orcid":false,"given":"Priya","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-4712","authenticated-orcid":false,"given":"Bo Gregers","family":"Winkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Karl","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-2623","authenticated-orcid":false,"given":"Christian","family":"J\u00f8ns","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Haarbo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte , Gentofte Hospitalsvej 1, 2900 Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-3554","authenticated-orcid":false,"given":"Jens","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-7948","authenticated-orcid":false,"given":"Jens Brock","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department fo Cardiology, Odense University Hospital , J B Winsl\u00f8ws Vej 4, 5000 Odense C , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-7601","authenticated-orcid":false,"given":"Berit T","family":"Philbert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-9463","authenticated-orcid":false,"given":"Sam","family":"Riahi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Hobrovej 18-22, 9000 Aalborg , Denmark"},{"name":"Department of Clinical Medicine, Aalborg University Hospital , Hobrovej 18-22, 9000 Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nordsjaellands Hospital , Dyrehavevej 29, 3400 Hiller\u00f8d , Denmark"},{"name":"Department of Public Health, University of Copenhagen , \u00d8ster Farimagsgade 5, 1353 Copenhagen K , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-9316","authenticated-orcid":false,"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"},{"name":"Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen , Frederik V's Vej 11, 2100 Copenhagen \u00d8 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-8864","authenticated-orcid":false,"given":"Peter E","family":"Weeke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital , Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"2023053015315882200_euad112-B1","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.jacc.2017.02.046","article-title":"Utility of post-mortem genetic testing in cases of sudden arrhythmic death syndrome","volume":"69","author":"Lahrouchi","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023053015315882200_euad112-B2","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients 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Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J"}],"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/5\/euad112\/50487362\/euad112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/5\/euad112\/50487362\/euad112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:32:46Z","timestamp":1685446366000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euad112\/7148055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,19]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euad112","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5]]},"article-number":"euad112"}}