{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:49Z","timestamp":1793831269063,"version":"4.6.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The epidemiology of sudden cardiac death (SCD) after heart transplantation (HTx) remains imprecisely described. We aimed to assess the incidence and determinants of SCD in a large cohort of HTx recipients, compared with the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive HTx recipients (n = 1246, 2 centres) transplanted between 2004 and 2016 were included. We prospectively assessed clinical, biological, pathologic, and functional parameters. SCD was centrally adjudicated. We compared the SCD incidence beyond the first year post-transplant in this cohort with that observed in the general population of the same geographic area (registry carried out by the same group of investigators; n = 19 706 SCD). We performed a competing risk multivariate Cox model to identify variables associated with SCD. The annual incidence of SCD was 12.5 per 1,000 person-years [95% confidence interval (CI), 9.7\u201315.9] in the HTx recipients cohort compared with 0.54 per 1,000 person-years (95% CI, 0.53\u20130.55) in the general population (P &amp;lt; 0.001). The risk of SCD was markedly elevated among the youngest HTx recipients with standardized mortality ratios for SCD up to 837 for recipients \u226430 years. Beyond the first year, SCD was the leading cause of death. Five variables were independently associated with SCD: older donor age (P = 0.003), younger recipient age (P = 0.001) and ethnicity (P = 0.034), pre-existing donor-specific antibodies (P = 0.009), and last left ventricular ejection fraction (P = 0.048).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>HTx recipients, particularly the youngest, were at very high risk of SCD compared with the general population. The consideration of specific risk factors may help identify high-risk subgroups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad126","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T01:37:03Z","timestamp":1684546623000},"source":"Crossref","is-referenced-by-count":11,"title":["Sudden cardiac death after heart transplantation: a population-based study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-1771","authenticated-orcid":false,"given":"Guillaume","family":"Bonnet","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"UMCV, Haut-L\u00e9v\u00eaque Hospital, University Hospital of Bordeaux , 33600 Pessac , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-2175","authenticated-orcid":false,"given":"Guillaume","family":"Coutance","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"Department of Cardiac and Thoracic Surgery, Cardiology Institute, Pitie\u0301-Salpe\u00eatrie\u0300re Hospital, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), Sorbonne University Medical School , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Aubert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"Kidney Transplant Department, Necker Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-1900","authenticated-orcid":false,"given":"Victor","family":"Waldmann","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"Cardiology and Heart Transplant department, European Georges Pompidou Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Rue Leblanc, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Raynaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-5475","authenticated-orcid":false,"given":"Anouk","family":"Asselin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-C\u00e9cile","family":"Bories","sequence":"additional","affiliation":[{"name":"Cardiology and Heart Transplant department, European Georges Pompidou Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Rue Leblanc, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-9876","authenticated-orcid":false,"given":"Romain","family":"Guillemain","sequence":"additional","affiliation":[{"name":"Cardiology and Heart Transplant department, European Georges Pompidou Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Rue Leblanc, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-2914","authenticated-orcid":false,"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[{"name":"Pathology Department, Georges Pompidou Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris. Universit\u00e9 de Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaida","family":"Varnous","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery, Cardiology Institute, Pitie\u0301-Salpe\u00eatrie\u0300re Hospital, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), Sorbonne University Medical School , Paris , France"},{"name":"INSERM, UMRS-1166, iCAN, Institute of Cardiometabolism and Nutrition, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Leprince","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery, Cardiology Institute, Pitie\u0301-Salpe\u00eatrie\u0300re Hospital, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), Sorbonne University Medical School , Paris , France"},{"name":"INSERM, UMRS-1166, iCAN, Institute of Cardiometabolism and Nutrition, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-6820","authenticated-orcid":false,"given":"Paul","family":"Achouch","sequence":"additional","affiliation":[{"name":"Cardiology and Heart Transplant department, European Georges Pompidou Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Rue Leblanc, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-3428","authenticated-orcid":false,"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"Cardiology and Heart Transplant department, European Georges Pompidou Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Rue Leblanc, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Loupy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"Kidney Transplant Department, Necker Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jouven","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM , UMR-S970, 75015 Paris , France"},{"name":"Cardiology and Heart Transplant department, European Georges Pompidou Hospital , Assistance Publique\u2014H\u00f4pitaux de Paris, Rue Leblanc, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"2023052001365502700_euad126-B1","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2023052001365502700_euad126-B2","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.healun.2019.08.004","article-title":"The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult heart transplantation report\u20142019; focus theme: donor and recipient size match","volume":"38","author":"Khush","year":"2019","journal-title":"J Hear Lung Transplant"},{"key":"2023052001365502700_euad126-B3","doi-asserted-by":"crossref","first-page":"e007954","DOI":"10.1161\/CIRCEP.120.007954","article-title":"Management of arrhythmias after heart transplant: current state and considerations for future research","volume":"14","author":"Joglar","year":"2021","journal-title":"Circ Arrhythmia Electrophysiol"},{"key":"2023052001365502700_euad126-B4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0002-8703(89)90670-4","article-title":"Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases","volume":"117","author":"de Luna","year":"1989","journal-title":"Am Heart J Mosby"},{"key":"2023052001365502700_euad126-B5","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13490","article-title":"The evolving risk of sudden cardiac death after heart transplant. 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