{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:50Z","timestamp":1792785890518,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Heart Foundation","award":["FLF102056"],"award-info":[{"award-number":["FLF102056"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["CDF1161506"],"award-info":[{"award-number":["CDF1161506"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Implantable cardioverter defibrillators (ICDs) prevent sudden cardiac death. Anxiety, depression, and post-traumatic stress disorder (PTSD) are underappreciated symptoms. We aimed to systematically synthesize prevalence estimates of mood disorders and symptom severities, pre- and post-ICD insertions. Comparisons were made with control groups, as well as within ICD patients by indication (primary vs. secondary), sex, shock status, and over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases (Medline, PsycINFO, PubMed, and Embase) were searched without limits from inception to 31 August 2022; 4661 articles were identified, 109 (39 954 patients) of which met criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Random-effects meta-analyses revealed clinically relevant anxiety in 22.58% (95%CI 18.26\u201326.91%) of ICD patients across all timepoints following insertion and depression in 15.42% (95%CI 11.90\u201318.94%). Post-traumatic stress disorder was seen in 12.43% (95%CI 6.90\u201317.96%). Rates did not vary relative to indication group. Clinically relevant anxiety and depression were more likely in ICD patients who experienced shocks [anxiety odds ratio (OR) = 3.92 (95%CI 1.67\u20139.19); depression OR = 1.87 (95%CI 1.34\u20132.59)]. Higher symptoms of anxiety were seen in females than males post-insertion [Hedges\u2019 g = 0.39 (95%CI 0.15\u20130.62)]. Depression symptoms decreased in the first 5 months post-insertion [Hedges\u2019 g = 0.13 (95%CI 0.03\u20130.23)] and anxiety symptoms after 6 months [Hedges\u2019 g = 0.07 (95%CI 0\u20130.14)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Depression and anxiety are highly prevalent in ICD patients, especially in those who experience shocks. Of particular concern is the prevalence of PTSD following ICD implantation. Psychological assessment, monitoring, and therapy should be offered to ICD patients and their partners as part of routine care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad130","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T19:19:45Z","timestamp":1684955985000},"source":"Crossref","is-referenced-by-count":76,"title":["Burden of mood symptoms and disorders in implantable cardioverter defibrillator patients: a systematic review and meta-analysis of 39 954 patients"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9122-6125","authenticated-orcid":false,"given":"Erica S","family":"Ghezzi","sequence":"first","affiliation":[{"name":"Cognitive Ageing and Impairment Neurosciences Laboratory, Justice and Society, University of South Australia , GPO Box 2741, Adelaide SA 5000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-2853","authenticated-orcid":false,"given":"Rhianna L S","family":"Sharman","sequence":"additional","affiliation":[{"name":"Cognitive Ageing and Impairment Neurosciences Laboratory, Justice and Society, University of South Australia , GPO Box 2741, Adelaide SA 5000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-4265","authenticated-orcid":false,"given":"Joseph B","family":"Selvanayagam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre , GPO Box 2100, Adelaide SA 5001 , Australia"},{"name":"Department of Medicine, School of Medicine and Public Health, Flinders University , GPO Box 2100, Adelaide SA 5001 , Australia"},{"name":"Lifelong Health Theme, South Australian Health and Medical Research Institute , North Terrace, Adelaide SA 5000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-5468","authenticated-orcid":false,"given":"Peter J","family":"Psaltis","sequence":"additional","affiliation":[{"name":"Lifelong Health Theme, South Australian Health and Medical Research Institute , North Terrace, Adelaide SA 5000 , Australia"},{"name":"Adelaide Medical School, University of Adelaide , North Terrace, Adelaide SA 5005 , Australia"},{"name":"Department of Cardiology, Royal Adelaide Hospital , Port Road, Adelaide SA 5000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-8429","authenticated-orcid":false,"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"Lifelong Health Theme, South Australian Health and Medical Research Institute , North Terrace, Adelaide SA 5000 , Australia"},{"name":"Adelaide Medical School, University of Adelaide , North Terrace, Adelaide SA 5005 , Australia"},{"name":"Department of Cardiology, Royal Adelaide Hospital , Port Road, Adelaide SA 5000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-1827","authenticated-orcid":false,"given":"Jack M","family":"Astley","sequence":"additional","affiliation":[{"name":"Cognitive Ageing and Impairment Neurosciences Laboratory, Justice and Society, University of South Australia , GPO Box 2741, Adelaide SA 5000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-9767","authenticated-orcid":false,"given":"Sara","family":"Knayfati","sequence":"additional","affiliation":[{"name":"Cognitive Ageing and Impairment Neurosciences Laboratory, Justice and Society, University of South Australia , GPO Box 2741, Adelaide SA 5000 , 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