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This symptom is now clearly differentiated from other forms of transient loss of consciousness. The critical role of vasodepression and\/or cardioinhibition as final mechanisms of reflex syncope is emphasized. Current diagnostic approach sharply separates between cardiac and autonomic pathways. Physiologic insights have been translated, through rigorously designed clinical trials, into non-pharmacological or pharmacological interventions and interventional therapies. The following manuscript is intended to give the reader the current state of the art of knowledge of syncope by highlighting landmark contributions of the Europace journal.<\/jats:p>","DOI":"10.1093\/europace\/euad163","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T11:14:29Z","timestamp":1692962069000},"source":"Crossref","is-referenced-by-count":48,"title":["Twenty-five years of research on syncope"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":false,"given":"Artur","family":"Fedorowski","sequence":"first","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital , Eugeniav\u00e4gen 3, 171 76 Solna, Stockholm , Sweden"},{"name":"Department of Medicine, Karolinska Institute , Solnav\u00e4gen 1, 171 77 Solna, Stockholm , Sweden"},{"name":"Department of Clinical Sciences, Lund University , 214 28 Malm\u00f6 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kulakowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Centre for Postgraduate Education, Grochowski Hospital , Ul. Grenadierow 51\/59, 04-073 Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-5607","authenticated-orcid":false,"given":"Michele","family":"Brignole","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. Luca Hospital, IRCCS, Istituto Auxologico Italiano , Piazzale Brescia 20, 20149 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-9230","authenticated-orcid":false,"given":"Frederik J","family":"de Lange","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105 AZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-8124","authenticated-orcid":false,"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, Trinity College Dublin , 152-160 Pearse St, Dublin , Ireland"},{"name":"Mercer Institute for Successful Ageing, St. James Hospital , James St, Dublin 8, D08 NHY1 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Moya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitari Dexeus , Carrer de Sabino Arana 5-19, 08028 Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-2242","authenticated-orcid":false,"given":"Giulia","family":"Rivasi","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Intensive Care Medicine, University of Florence and Azienda Ospedaliero-Universitaria Careggi , Largo Brambilla 3, 50139 Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-4082","authenticated-orcid":false,"given":"Robert","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, University of Calgary , Libin Cardiovascular Institute, 3310 Hospital Drive NW, Calgary, Alberta T2N 4N1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-7573","authenticated-orcid":false,"given":"Gert","family":"Van Dijk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Canisius Wilhelmina Hospital , Weg door Jonkerbos 100, 6532 SZ, Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-1094","authenticated-orcid":false,"given":"Richard","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hammersmith Hospital, National Heart & Lung Institute , Imperial College, Du Cane Road, London, W12 0HS , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-3845","authenticated-orcid":false,"given":"Jean-Claude","family":"Deharo","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2212 H\u00f4pitaux de Marseille, Centre Hospitalier Universitaire La Timone, Service de Cardiologie, Marseille, France and Aix Marseille Universit\u00e9 , C2VN, 264 Rue Saint-Pierre, 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"2023082511125627000_euad163-B1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/eupc.2001.0190","article-title":"Task force on syncope, European Society of Cardiology. 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