{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:38:17Z","timestamp":1790181497270,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["20-R140-A9569-22168"],"award-info":[{"award-number":["20-R140-A9569-22168"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018781","name":"Danish Children\u2019s Heart Foundation","doi-asserted-by":"publisher","award":["19-R112-A5248-26048"],"award-info":[{"award-number":["19-R112-A5248-26048"]}],"id":[{"id":"10.13039\/100018781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Snedkermester Sophus Jacobsen"},{"name":"wife Astrid Jacobsens foundation"},{"name":"Murermester Lauritz Peter Christensen"},{"name":"wife Kirsten Sigrid Christensens foundation"},{"name":"The Research Council at Herlev\u2013Gentofte Hospital"},{"name":"The Health Foundation Denmark"},{"name":"The Independent Research Fund Denmark","award":["0134-00363B"],"award-info":[{"award-number":["0134-00363B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Wolff\u2013Parkinson\u2013White (WPW) syndrome is a conduction disorder characterized by an accessory electrical pathway between the atria and ventricles, which may predispose to supraventricular tachycardia (SVT) and sudden cardiac death. It can be seen as an isolated finding or associated with structural heart disease. Our aims were to determine the prevalence of a WPW pattern in a large and unselected cohort of neonates and to describe the electro- and echocardiographic characteristics as well as the natural history during early childhood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Electrocardiograms and echocardiograms of neonates (aged 0\u201330 days) from a large, prospective, population-based cohort study were included. Neonates with a WPW pattern were identified and matched 1:4 to controls. Localization of the accessory pathway was assessed by different algorithms. Among 17 489 neonates, we identified 17 (76% boys) with a WPW pattern consistent with a prevalence of 0.1%. One neonate had moderate mitral regurgitation while other echocardiographic parameters were similar between cases and controls (all P &amp;gt; 0.05). The accessory pathways were primarily predicted to be left-sided. At follow-up (available in 14\/17 children; mean age 3.2 years) the pre-excitation pattern persisted in only four of the children and none of the children had experienced any episodes of SVT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of a WPW pattern in our cohort of unselected neonates was 0.1%. The WPW pattern was more frequent in boys and generally not associated with structural heart disease, and the accessory pathways were primarily left-sided. At follow-up, the WPW pattern had disappeared in most of the children suggesting either an intermittent nature or that normalization occurs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>Copenhagen Baby Heart, NCT02753348.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad165","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T08:38:55Z","timestamp":1689755935000},"source":"Crossref","is-referenced-by-count":15,"title":["The Wolff\u2013Parkinson\u2013White pattern in neonates: results from a large population-based cohort study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-6077","authenticated-orcid":false,"given":"Maria Munk","family":"P\u00e6rregaard","sequence":"first","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-3746","authenticated-orcid":false,"given":"Joachim","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-1016","authenticated-orcid":false,"given":"Anne-Sophie","family":"Sillesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-9488","authenticated-orcid":false,"given":"Christian","family":"Pihl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-1514","authenticated-orcid":false,"given":"Sofie","family":"Dannesbo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"},{"name":"Department of Cardiology, The Capital Regions Unit for Inherited Cardiac Diseases, The Heart Center, Rigshospitalet, Copenhagen University Hospital , Inge Lehmanns Vej 7, DK-2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-0363","authenticated-orcid":false,"given":"Thilde Olivia","family":"Kock","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Pietersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-3309","authenticated-orcid":false,"given":"Anna Axelsson","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Capital Regions Unit for Inherited Cardiac Diseases, The Heart Center, Rigshospitalet, Copenhagen University Hospital , Inge Lehmanns Vej 7, DK-2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-8487","authenticated-orcid":false,"given":"Kasper Karmark","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev\u2013Gentofte Hospital, Copenhagen University Hospital , Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, DK-2200 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Capital Regions Unit for Inherited Cardiac Diseases, The Heart Center, Rigshospitalet, Copenhagen University Hospital , Inge Lehmanns Vej 7, 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