{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:52:47Z","timestamp":1773809567012,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["EC08\/0296"],"award-info":[{"award-number":["EC08\/0296"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>Bayesian analyses can provide additional insights into the results of clinical trials, aiding in the decision-making process. We analysed the Substrate Ablation vs. Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia (SURVIVE-VT) trial using Bayesian survival models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The SURVIVE-VT trial randomized patients with ischaemic cardiomyopathy and monomorphic ventricular tachycardia (VT) to catheter ablation or antiarrhythmic drugs (AAD) as a first-line strategy. The primary outcome was a composite of cardiovascular death, appropriate implantable cardioverter\u2013defibrillator shocks, unplanned heart failure hospitalizations, or severe treatment-related complications. We used informative, skeptical, and non-informative priors with different probabilities of large effects to compute the posterior distributions using Markov Chain Monte Carlo methods. We calculated the probabilities of hazard ratios (HR) being &amp;lt;1, &amp;lt;0.9, and &amp;lt;0.75, as well as 2-year survival estimates. Of the 144 randomized patients, 71 underwent catheter ablation and 73 received AAD. Regardless of the prior, catheter ablation had a &amp;gt;98% probability of reducing the primary outcome (HR &amp;lt; 1) and a &amp;gt;96% probability of achieving a reduction of &amp;gt;10% (HR &amp;lt; 0.9). The probability of a &amp;gt;25% (HR &amp;lt; 0.75) reduction of treatment-related complications was &amp;gt;90%. Catheter ablation had a high probability (&amp;gt;93%) of reducing incessant\/slow undetected VT\/electric storm, unplanned hospitalizations for ventricular arrhythmias, and overall cardiovascular admissions &amp;gt; 25%, with absolute differences of 15.2%, 21.2%, and 20.2%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with ischaemic cardiomyopathy and VT, catheter ablation as a first-line therapy resulted in a high probability of reducing several clinical outcomes compared to AAD. Our study highlights the value of Bayesian analysis in clinical trials and its potential for guiding treatment decisions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial Registration<\/jats:title>\n                  <jats:p>ClinicalTrials.gov identifier: NCT03734562<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad181","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T12:19:45Z","timestamp":1687868385000},"source":"Crossref","is-referenced-by-count":7,"title":["Bayesian analysis of the Substrate Ablation vs. Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia trial"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-8769","authenticated-orcid":false,"given":"Pablo","family":"\u00c1vila","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, IiSGM, Universidad Complutense, CIBERCV , Dr Esquerdo 46, 28007, Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-383X","authenticated-orcid":false,"given":"Antonio","family":"Berruezo","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Hospital Clinic and Teknon Medical Centre , c\/Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1831-8730","authenticated-orcid":false,"given":"Javier","family":"Jim\u00e9nez-Candil","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, IBSAL-Hospital Universitario, Universidad de Salamanca, CIBERCV , Paseo San Vicente 58-182, 37007, Salamanca , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-8809","authenticated-orcid":false,"given":"Luis","family":"Tercedor","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Hospital Universitario Virgen de las Nieves , Avd. Fuerzas Armadas 2, 18014, Granada , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-4011","authenticated-orcid":false,"given":"David","family":"Calvo","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , Avd Roma, s\/n, 33011, Oviedo , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Hospital Cl\u00ednico San Carlos , Prof Mart\u00edn Lagos, S\/N, Madrid, 28040 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-7923","authenticated-orcid":false,"given":"Fernando","family":"Arribas","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Doce de Octubre , Av. de C\u00f3rdoba, s\/n, 28041, Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-0035","authenticated-orcid":false,"given":"Javier","family":"Fern\u00e1ndez-Portales","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complejo Hospitalario Universitario de C\u00e1ceres , Av. de la Universidad 75, 10004, C\u00e1ceres , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-1903","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Merino","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Hospital Universitario La Paz, IdiPAZ, Universidad Aut\u00f3noma , P.\u00ba de la Castellana 261, 28046, Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Hern\u00e1ndez-Madrid","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares , 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