{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:55:10Z","timestamp":1792090510933,"version":"4.4.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"EACVI Research Grant"},{"name":"Academy Van Leersum"},{"name":"Academy Medical Sciences Fund"},{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Arts & Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Heart Institute Fellowship"},{"name":"CVON PREDICT2 Young Talent Program"},{"name":"NIHR Biomedical Research Centre"},{"DOI":"10.13039\/501100004941","name":"St Thomas\u2019 NHS Foundation Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009360","name":"King\u2019s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023312","name":"Wellcome EPSRC Centre for Medical Engineering","doi-asserted-by":"publisher","award":["WT 203148\/Z\/16\/Z"],"award-info":[{"award-number":["WT 203148\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/501100023312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023312","name":"Wellcome EPSRC Centre for Medical Engineering","doi-asserted-by":"publisher","award":["213342\/Z\/18\/Z"],"award-info":[{"award-number":["213342\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/501100023312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/18\/74\/34077"],"award-info":[{"award-number":["PG\/18\/74\/34077"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Substrate assessment of scar-mediated ventricular tachycardia (VT) is frequently performed using late gadolinium enhancement (LGE) images. Although this provides structural information about critical pathways through the scar, assessing the vulnerability of these pathways for sustaining VT is not possible with imaging alone.<\/jats:p>\n                    <jats:p>This study evaluated the performance of a novel automated re-entrant pathway finding algorithm to non-invasively predict VT circuit and inducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty post-infarct VT-ablation patients were included for retrospective analysis. Commercially available software (ADAS3D left ventricular) was used to generate scar maps from 2D-LGE images using the default 40\u201360 pixel-signal-intensity (PSI) threshold. In addition, algorithm sensitivity for altered thresholds was explored using PSI 45\u201355, 35\u201365, and 30\u201370. Simulations were performed on the Virtual Induction and Treatment of Arrhythmias (VITA) framework to identify potential sites of block and assess their vulnerability depending on the automatically computed round-trip-time (RTT). Metrics, indicative of substrate complexity, were correlated with VT-recurrence during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total VTs (85 \u00b1 43 vs. 42 \u00b1 27) and unique VTs (9 \u00b1 4 vs. 5 \u00b1 4) were significantly higher in patients with- compared to patients without recurrence, and were predictive of recurrence with area under the curve of 0.820 and 0.770, respectively. VITA was robust to scar threshold variations with no significant impact on total and unique VTs, and mean RTT between the four models. Simulation metrics derived from PSI 45\u201355 model had the highest number of parameters predictive for post-ablation VT-recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Advanced computational metrics can non-invasively and robustly assess VT substrate complexity, which may aid personalized clinical planning and decision-making in the treatment of post-infarction VT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad198","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T16:46:22Z","timestamp":1688748382000},"source":"Crossref","is-referenced-by-count":22,"title":["Arrhythmogenic vulnerability of re-entrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-9304","authenticated-orcid":false,"given":"Pranav","family":"Bhagirath","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital , London SE1 7EH , UK"},{"name":"Department of Cardiology, St Thomas' Hospital , London SE1 7EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-0094","authenticated-orcid":false,"given":"Fernando O","family":"Campos","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital , London SE1 7EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":false,"given":"Pieter G","family":"Postema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-5660","authenticated-orcid":false,"given":"Michiel J B","family":"Kemme","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-0852","authenticated-orcid":false,"given":"Arthur A M","family":"Wilde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-1377","authenticated-orcid":false,"given":"Anton 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