{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:05Z","timestamp":1791266945605,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Sudden cardiac death (SCD) is challenging to predict. Electrocardiogram (ECG)-derived heart rate-corrected QT-interval (QTc) is used for SCD-risk assessment. QTc is preferably determined manually, but vendor-provided automatic results from ECG recorders are convenient. Agreement between manual and automatic assessments is unclear for populations with aberrant QTc. We aimed to systematically assess pairwise agreement of automatic and manual QT-intervals and QTc.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A multi-centre cohort enriching aberrant QTc comprised ECGs of healthy controls and long-QT syndrome (LQTS) patients. Manual QT-intervals and QTc were determined by the tangent and threshold methods and compared to automatically generated, vendor-provided values. We assessed agreement globally by intra-class correlation coefficients and pairwise by Bland\u2013Altman analyses and 95% limits of agreement (LoA). Further, manual results were compared to a novel automatic QT-interval algorithm. ECGs of 1263 participants (720 LQTS patients; 543 controls) were available [median age 34 (inter-quartile range 35) years, 55% women]. Comparing cohort means, automatic and manual QT-intervals and QTc were similar. However, pairwise Bland\u2013Altman-based agreement was highly discrepant. For QT-interval, LoAs spanned 95 (tangent) and 92\u2005ms (threshold), respectively. For QTc, the spread was 108 and 105\u2005ms, respectively. LQTS patients exhibited more pronounced differences. For automatic QTc results from 440\u2013540\u2005ms (tangent) and 430\u2013530\u2005ms (threshold), misassessment risk was highest. Novel automatic QT-interval algorithms may narrow this range.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pairwise vendor-provided automatic and manual QT-interval and QTc results can be highly discrepant. Novel automatic algorithms may improve agreement. Within the above ranges, automatic QT-interval and QTc results require manual confirmation, particularly if T-wave morphology is challenging.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad213","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T15:21:17Z","timestamp":1689866477000},"source":"Crossref","is-referenced-by-count":31,"title":["Manual vs. automatic assessment of the QT-interval and corrected QT"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5169-8053","authenticated-orcid":false,"given":"Benjamin","family":"Neumann","sequence":"first","affiliation":[{"name":"Department of Medicine I, LMU University Hospital, LMU Munich , Munich , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-7967","authenticated-orcid":false,"given":"A Suzanne","family":"Vink","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center , Amsterdam , The Netherlands"},{"name":"Department of Pediatric Cardiology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7780-4427","authenticated-orcid":false,"given":"Ben J M","family":"Hermans","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Maastricht University , Maastricht , The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-5552","authenticated-orcid":false,"given":"Krystien V V","family":"Lieve","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-4380","authenticated-orcid":false,"given":"Didem","family":"C\u00f6mert","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt-Maria","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Department of Medicine I, LMU University Hospital, LMU Munich , Munich , Germany"},{"name":"Department of Legal Medicine, Goethe Univeristy, University Hospital Frankfurt , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5276-1475","authenticated-orcid":false,"given":"Sally-Ann B","family":"Clur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-6974","authenticated-orcid":false,"given":"Nico A","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , The Netherlands"},{"name":"Department of Pediatric Cardiology, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-9700","authenticated-orcid":false,"given":"Tammo","family":"Delhaas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Maastricht University , Maastricht , The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-0852","authenticated-orcid":false,"given":"Arthur A M","family":"Wilde","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center , Amsterdam , The Netherlands"},{"name":"Department of Pediatric Cardiology, Leiden University Medical Center , Leiden , The Netherlands"},{"name":"Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders , Jeddah, Kingdom of Saudi Arabia"},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam University Medical Center , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-3581","authenticated-orcid":false,"given":"Stefan","family":"K\u00e4\u00e4b","sequence":"additional","affiliation":[{"name":"Department of Medicine I, LMU University Hospital, LMU Munich , Munich , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-9159","authenticated-orcid":false,"given":"Pieter G","family":"Postema","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center , Amsterdam , The 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