{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:41:51Z","timestamp":1788536511781,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"TYRX Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Infections resulting from cardiac implantable electronic device (CIED) implantation are severely impacting on patients\u2019 and on health care systems. The use of TYRXTM absorbable antibiotic-eluting envelope has proven to decrease major CIED infections within 12 months of CIED surgery. The aim is to evaluate the impact of the envelope use on infection-related clinical events in a real-world contemporary patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Data on patients undergoing CIED surgery were collected prospectively by participating centers of the One Hospital ClinicalService project. Patients were divided into two groups according to whether TYRXTM absorbable antibiotic-eluting envelope was used or not. Out of 1819 patients, 872 (47.9%) were implanted with an absorbable antibiotic-eluting envelope and included in the Envelope group and 947 (52.1%) patients who did not receive an envelope were included in the Control group. Compared to control, patients in the Envelope group had higher thrombo-embolic or hemorrhagic risk, higher BMI, lower LVEF and more comorbidities. During a mean follow-up of 1.4 years, the incidence of infection-related events was significantly higher in the control compared to the Envelope group (2.4% vs. 0.8%, P = 0.007). The five-year cumulative incidence of infection-related events was 8.1% in the control and 2.1% in the Envelope group (HR: 0.34, 95%CI: 0.14\u20130.80, P = 0.010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our analysis, the use of an absorbable antibiotic-eluting envelope in the general CIED population was associated with a lower risk of systemic and pocket infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad224","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:43:37Z","timestamp":1690274617000},"source":"Crossref","is-referenced-by-count":27,"title":["REducing INFectiOns thRough Cardiac device Envelope: insight from real world data. The REINFORCE project"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-2739","authenticated-orcid":false,"given":"Matteo","family":"Ziacchi","sequence":"first","affiliation":[{"name":"Institute of Cardiology, IRCCS Azienda Ospedaliero Universitaria di Bologna , Via Massarenti 9, 40125 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8584","authenticated-orcid":false,"given":"Mauro","family":"Biffi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, IRCCS Azienda Ospedaliero Universitaria di Bologna , Via Massarenti 9, 40125 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"GVM, Maria Cecilia Hospital , Cotignola"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-2969","authenticated-orcid":false,"given":"Michele","family":"di Silvestro","sequence":"additional","affiliation":[{"name":"Umberto I , Enna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-9214","authenticated-orcid":false,"given":"Procolo","family":"Marchese","sequence":"additional","affiliation":[{"name":"Presidio ospedaliero G. Mazzoni , Ascoli Piceno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7830-1531","authenticated-orcid":false,"given":"Francesca","family":"Miscio","sequence":"additional","affiliation":[{"name":"Ospedale \u2018Teresa Masselli Mascia\u2019 , San Severo, Foggia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo Paolo","family":"Caccavo","sequence":"additional","affiliation":[{"name":"Ospedale F. Miulli , Acqua Viva delle Fonti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Zanotto","sequence":"additional","affiliation":[{"name":"Ospedale Mater Salutis di Legnago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tomasi","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria di Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-421X","authenticated-orcid":false,"given":"Antonio","family":"Dello Russo","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria delle Marche , Ancona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-2159","authenticated-orcid":false,"given":"Luca","family":"Donazzan","sequence":"additional","affiliation":[{"name":"Cardiology Department, Ospedale San Maurizio , Bolzano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4815","authenticated-orcid":false,"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"2023111015060269800_euad224-B1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/europace\/euz246","article-title":"European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections-endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"22","author":"Blomstr\u00f6m-Lundqvist","year":"2020","journal-title":"Europace"},{"key":"2023111015060269800_euad224-B2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/europace\/euv260","article-title":"Infection control in implantation of cardiac implantable electronic devices: current evidence, controversial points, and unresolved issues","volume":"18","author":"Korantzopoulos","year":"2016","journal-title":"Europace"},{"key":"2023111015060269800_euad224-B3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.17219\/acem\/80665","article-title":"Infections of cardiac implantable electronic devices: epidemiology, classification, treatment, and prognosis","volume":"28","author":"S\u0142awi\u0144ski","year":"2019","journal-title":"Adv Clin Exp 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