{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:31:18Z","timestamp":1772069478270,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Left atrial appendage occlusion (LAAO) with WATCHMAN device is being used for patients with atrial fibrillation (AFB) and, as an off-label use, atrial flutter (AFL) who can't comply with long-term anticoagulation. We aim to study the differences in outcomes between sexes in patients undergoing Watchman device implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methodology<\/jats:title>\n                  <jats:p>The National Inpatient Sample was queried between 2016 and 2019 using ICD-10 clinical modification codes I48x for AFB and AFL. Patients who underwent LAAO were identified using the procedural code 02L73DK. Comorbidities and complications were identified using ICD procedure and diagnosis codes. Differences in primary outcomes were analyzed using multivariable regression and propensity score matching.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>38 105 admissions were identified, of which 16 795 (44%) were females (76 \u00b1 7.6 years) and 21 310 (56%) were males (75 \u00b1 8 years). Females were more likely to have cardiac (frequencies: 5.8% vs 3.75%, aOR: 1.5 [1.35-1.68], p1 day inpatient (1.79 [1.67-1.93], P &amp;lt; 0.01) and be discharged to a facility (1.54 [1.33-1.80], P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Females are more likely to develop cardiac, renal, bleeding, pulmonary and TEE-related complications following LAAO procedure, while concurrently showing higher mortality, length of stay and discharge to facilities.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad228","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T12:33:09Z","timestamp":1690547589000},"source":"Crossref","is-referenced-by-count":6,"title":["Comparison of in-hospital outcomes and complications of left atrial appendage closure with the Watchman device between males and females"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-1496","authenticated-orcid":false,"given":"Majd Al Deen","family":"Alhuarrat","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-2664","authenticated-orcid":false,"given":"Sumant","family":"Pargaonkar","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6768-9768","authenticated-orcid":false,"given":"Kusha","family":"Rahgozar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine , 111 East 210th Street, Bronx, NY 10467 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-6430","authenticated-orcid":false,"given":"Israel","family":"Safiriyu","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-943X","authenticated-orcid":false,"given":"Xiadong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine , 111 East 210th Street, Bronx, NY 10467 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T","family":"Faillace","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":false,"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine , 111 East 210th Street, Bronx, NY 10467 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"2023082310335540700_euad228-B1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/europace\/euaa423","article-title":"Antithrombotic therapy for stroke prevention in patients with atrial fibrillation who survive an intracerebral haemorrhage: results of an EHRA survey","volume":"23","author":"Ivany","year":"2021","journal-title":"Europace"},{"key":"2023082310335540700_euad228-B2","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1016\/j.jacc.2017.10.021","article-title":"5-year outcomes after left atrial appendage closure: from the PREVAIL and PROTECT AF trials","volume":"70","author":"Reddy","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023082310335540700_euad228-B3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cjca.2019.08.012","article-title":"Trends of sex differences in outcomes of cardiac electronic device implantations in the United States","volume":"36","author":"Mohamed","year":"2020","journal-title":"Can J Cardiol"},{"key":"2023082310335540700_euad228-B4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/CIRCULATIONAHA.110.976449","article-title":"Safety of percutaneous left atrial appendage closure: results from the Watchman Left Atrial Appendage System for Embolic Protection in Patients with AF (PROTECT AF) clinical trial and the Continued Access Registry","volume":"123","author":"Reddy","year":"2011","journal-title":"Circulation"},{"key":"2023082310335540700_euad228-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","article-title":"Prospective randomized evaluation of the Watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial","volume":"64","author":"Holmes","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2023082310335540700_euad228-B6","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.jcin.2022.06.037","article-title":"Sex differences in safety and effectiveness of LAAO: insights from the Amulet IDE trial","volume":"15","author":"Alkhouli","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"2023082310335540700_euad228-B7","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/jamacardio.2021.3021","article-title":"Sex differences in procedural outcomes among patients undergoing left atrial appendage occlusion: insights from the NCDR LAAO registry","volume":"6","author":"Darden","year":"2021","journal-title":"JAMA Cardiol"},{"key":"2023082310335540700_euad228-B8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/europace\/euac021","article-title":"Watchman FLX vs. Watchman 2.5 in a dual-center left atrial appendage closure cohort: the WATCH-DUAL study","volume":"24","author":"Galea","year":"2022","journal-title":"Europace"},{"key":"2023082310335540700_euad228-B9","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/clc.23696","article-title":"Safety and efficacy of left atrial appendage occlusion with the ACP or Watchman device guided by intracardiac echocardiography from the left atrium","volume":"44","author":"Pommier","year":"2021","journal-title":"Clin Cardiol"},{"key":"2023082310335540700_euad228-B10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ccd.26805","article-title":"Intracardiac versus transesophageal echocardiography for left atrial appendage occlusion with Watchman","volume":"90","author":"Frangieh","year":"2017","journal-title":"Catheter Cardiovasc Interv"},{"key":"2023082310335540700_euad228-B11","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1111\/jce.15220","article-title":"Intracardiac echocardiography- versus transesophageal echocardiography-guided left atrial appendage occlusion with Watchman FLX","volume":"32","author":"Gianni","year":"2021","journal-title":"J Cardiovasc Electrophysiol"}],"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euad228\/50983672\/euad228.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/9\/euad228\/51231842\/euad228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/9\/euad228\/51231842\/euad228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:37:54Z","timestamp":1692787074000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euad228\/7232784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8,2]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euad228","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,7,28]]},"article-number":"euad228"}}