{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:19:19Z","timestamp":1781360359254,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"commercial"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Since their introduction in 1958, traditional cardiac pacemakers have undergone considerable upgrades over the years, but they continue to have a complication rate of \u223c3.8%\u201312.4%. There are no randomized controlled trials comparing outcomes of leadless pacemakers (LPM) with single-chamber transvenous pacemakers (TV-VVI). The aim is to assess the differences in the procedural complications and in-hospital outcomes between LPM and TV-VVI implants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We queried the national inpatient database from 2016 to 2019 to include adult patients undergoing LPM and TV-VVI. Admissions for leadless and single-lead transvenous pacemakers were identified by their appropriate ICD-10 codes. Complications were identified using ICD-10 codes that mostly represent initial encounter. The difference in outcomes was assessed using multivariable logistic regression and 1:1 propensity score matching between the two cohorts. Thirty-five thousand four hundred thirty expanded samples of admissions were retrieved of which 27 650 (78%) underwent TV-VVI with a mean age 81.3 \u00b1 9.4 years and 7780 (22%) underwent LPM with a mean age of 77.1 \u00b1 12.1 years. The LPM group had a higher likelihood of in-hospital mortality [adjusted odds ratio (aOR): 1.63, 95% CI (1.29\u20132.05), P &amp;lt; 0.001], vascular complications [aOR: 7.54, 95% CI (3.21\u201317.68), P &amp;lt; 0.001], venous thromboembolism [aOR: 3.67, 95% CI (2.68\u20135.02), P &amp;lt; 0.001], cardiac complications [aOR: 1.79, 95% CI (1.59\u20132.03), P &amp;lt; 0.001], device thrombus formation [aOR: 5.03, 95% CI (2.55\u20139.92), P &amp;lt; 0.001], and need for a blood transfusion [aOR: 1.54, 95% CI (1.14\u20132.07), P &amp;lt; 0.005]. The TV-VVI group had higher likelihood of in-hospital pulmonary complications [aOR:0.68, 95% CI (0.54\u20130.87), P &amp;lt; 0.002] and had a need for device revisions [aOR:0.42, 95% CI (0.23\u20130.76), P &amp;lt; 0.004].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There is a higher likelihood of all-cause in-hospital mortality and complications following LPM implantation in comparison to TV-VVI. This could be related to higher co-morbidities in the LPM group. Clinical trials aimed to accurately compare these two groups should be undertaken.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad269","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:09:29Z","timestamp":1694718569000},"source":"Crossref","is-referenced-by-count":37,"title":["Comparison of in-hospital outcomes and complications of leadless pacemaker and traditional transvenous pacemaker implantation"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-1496","authenticated-orcid":false,"given":"Majd Al Deen","family":"Alhuarrat","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-4489","authenticated-orcid":false,"given":"Amrin","family":"Kharawala","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-0529","authenticated-orcid":false,"given":"Sarath","family":"Renjithlal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester Regional Health\/Unity Hospital , Rochester, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6102-479X","authenticated-orcid":false,"given":"Mohamed","family":"Magdi Eid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester Regional Health\/Unity Hospital , Rochester, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-1728","authenticated-orcid":false,"given":"Dimitrios","family":"Varrias","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-4922","authenticated-orcid":false,"given":"Moghniuddin","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rochester Regional Health , Rochester, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grushko","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center, Albert Einstein College Medicine , Bronx, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":false,"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine , 111 East 210th Street, Bronx, NY 10467 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,15]]},"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euad269\/51563356\/euad269.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/9\/euad269\/51732171\/euad269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/9\/euad269\/51732171\/euad269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:00:39Z","timestamp":1695499239000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euad269\/7274340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8,2]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euad269","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,8,2]]},"article-number":"euad269"}}