{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:59:59Z","timestamp":1790402399728,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"American Heart Association and the Chinese Society of Cardiology"},{"DOI":"10.13039\/100000968","name":"The American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The clinical correlates and outcomes of asymptomatic atrial fibrillation (AF) in hospitalized patients are largely unknown. We aimed to investigate the clinical correlates and in-hospital outcomes of asymptomatic AF in hospitalized Chinese patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a cross-sectional registry study of inpatients with AF enrolled in the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation Project between February 2015 and December 2019. We investigated the clinical characteristics of asymptomatic AF and the association between the clinical correlates and the in-hospital outcomes of asymptomatic AF. Asymptomatic and symptomatic AF were defined according to the European Heart Rhythm Association score. Asymptomatic patients were more commonly males (56.3%) and had more comorbidities such as hypertension (57.4%), diabetes mellitus (18.6%), peripheral artery disease (PAD; 2.3%), coronary artery disease (55.5%), previous history of stroke\/transient ischaemic attack (TIA; 17.9%), and myocardial infarction (MI; 5.4%); however, they had less prevalent heart failure (9.6%) or left ventricular ejection fractions \u226440% (7.3%). Asymptomatic patients were more often hospitalized with a non-AF diagnosis as the main diagnosis and were more commonly first diagnosed with AF (23.9%) and long-standing persistent\/permanent AF (17.0%). The independent determinants of asymptomatic presentation were male sex, long-standing persistent AF\/permanent AF, previous history of stroke\/TIA, MI, PAD, and previous treatment with anti-platelet drugs. The incidence of in-hospital clinical events such as all-cause death, ischaemic stroke\/TIA, and acute coronary syndrome (ACS) was higher in asymptomatic patients than in symptomatic patients, and asymptomatic clinical status was an independent risk factor for in-hospital all-cause death, ischaemic stroke\/TIA, and ACS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Asymptomatic AF is common among hospitalized patients with AF. Asymptomatic clinical status is associated with male sex, comorbidities, and a higher risk of in-hospital outcomes. The adoption of effective management strategies for patients with AF should not be solely based on clinical symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad272","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:50:48Z","timestamp":1694717448000},"source":"Crossref","is-referenced-by-count":18,"title":["Asymptomatic atrial fibrillation among hospitalized patients: clinical correlates and in-hospital outcomes in Improving Care for Cardiovascular Disease in China-Atrial Fibrillation"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-0480","authenticated-orcid":false,"given":"Jing","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-045X","authenticated-orcid":false,"given":"Xue-Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-5346","authenticated-orcid":false,"given":"De-Yong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Xi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4421","authenticated-orcid":false,"given":"Cai-Hua","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-1827","authenticated-orcid":false,"given":"Ri-Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-663X","authenticated-orcid":false,"given":"Song-Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"},{"name":"National Clinical Research Center for Cardiovascular Diseases , 2 Anzhen Road, Chaoyang District, Beijing 100029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-0844","authenticated-orcid":false,"given":"Zhao-Qing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-171X","authenticated-orcid":false,"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , 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C","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of North Carolina , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital , Liverpool , UK"},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-3449","authenticated-orcid":false,"given":"Dong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , 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