{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:43:31Z","timestamp":1788227011388,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","award":["NCT02006069"],"award-info":[{"award-number":["NCT02006069"]}],"id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the impact of MultiPoint\u2122 Pacing (MPP) in cardiac resynchronization therapy (CRT) non-responders after 6 months of standard biventricular pacing (BiVP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The trial enrolled 5850 patients who planned to receive a CRT device. The echocardiography core laboratory assessed CRT response before implant and after 6 months of BiVP; non-response to BiVP was defined as &amp;lt;15% relative reduction in left ventricular end-systolic volume (LVESV). Echocardiographic non-responders were randomized in a 1:1 ratio to receive MPP (541 patients) or continued BiVP (570 patients) for an additional 6 months and evaluated the conversion rate to the echocardiographic response. The characteristics of both groups at randomization were comparable. The percentage of non-responder patients who became responders to CRT therapy was 29.4% in the MPP arm and 30.4% in the BIVP arm (P = 0.743). In patients with \u226530\u2005mm spacing between the two left ventricular pacing sites (MPP-AS), identified during the first phase as a potential beneficial subgroup, no significant difference in the conversion rate was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our trial shows that \u223c30% of patients, who do not respond to CRT in the first 6 months, experience significant reverse remodelling in the following 6 months. This finding suggests that CRT benefit may be delayed or slowly incremental in a relevant proportion of patients and that the percentage of CRT responders may be higher than what has been described in short-\/middle-term studies. MultiPoint\u2122 Pacing does not improve CRT response in non-responders to BiVP, even with MPP-AS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad294","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T16:54:34Z","timestamp":1695920074000},"source":"Crossref","is-referenced-by-count":40,"title":["Cardiac resynchronization therapy non-responder to responder conversion rate in the MORE-CRT MPP trial"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-5568","authenticated-orcid":false,"given":"Christophe","family":"Leclercq","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Rennes I, CICIT 804, CHU Pontchaillou Rennes Service de Cardiologie et Maladies Vasculaires, , 2, rue Henri le Guilloux 35033 Rennes C\u00e9dex 09 , Rennes 35033, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-5338","authenticated-orcid":false,"given":"Haran","family":"Burri","sequence":"additional","affiliation":[{"name":"University of Geneva Departement of Cardiology, , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Paul","family":"Delnoy","sequence":"additional","affiliation":[{"name":"Isala Klinieken Isala Hospital, Department of Cardiology, , Zwolle , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-1957","authenticated-orcid":false,"given":"Christopher A","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"King\u2019s College , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sperzel","sequence":"additional","affiliation":[{"name":"Kerckhoff Klinik The Kerckhoff Heart and Thorax Center, Bad Nauheim, , Bad 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