{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:35:11Z","timestamp":1787319311432,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ablacon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Validating mapping systems that identify atrial fibrillation (AF) sources (focal\/rotational activity) is confounded by the absence of ground truth. A key concern of prior mapping technologies is spatiotemporal instability, manifesting as poor map reproducibility. Electrographic flow (EGF) employs a novel algorithm that visualizes atrial electrical wavefront propagation to identify putative AF sources. We analysed both intra- (3\u2005min) and inter- (&amp;gt;3 months) procedure EGF map reproducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In 23 persistent AF patients, after pulmonary vein isolation (PVI), EGF maps were generated from 3 serial 1\u2005min recordings using a 64-electrode basket mapping catheter (triplets) at right and left atrial locations. Source prevalence from map triplets was compared between recordings. Per protocol, 12 patients returned for 3-month remapping (1 non-inducible): index procedure post-PVI EGF maps were compared with initial EGF remapping at 3-month redo. Intra-procedure reproducibility: analysing 224 map triplets (111 right atrium, 113 left atrium) revealed a high degree of map consistency with minimal min-to-min shifts: 97 triplets (43%), exact match of leading sources on all 3 maps; 95 triplets (42%), leading source within 1 electrode space on 2 of 3 maps; and 32 triplets (14%), chaotic leading source pattern. Average deviation in source prevalence over 60\u2005s was low (6.4%). Inter-procedure reproducibility: spatiotemporal stability of EGF mapping &amp;gt;3 months was seen in 16 of 18 (89%) sources mapped in 12 patients with (re)inducible AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Electrographic flow mapping generates reproducible intra- and inter-procedural maps, providing rationale for randomized clinical trials targeting these putative AF sources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad308","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T17:31:40Z","timestamp":1699551100000},"source":"Crossref","is-referenced-by-count":7,"title":["Electrographic flow mapping of persistent atrial fibrillation: intra- and inter-procedure reproducibility in the absence of \u2018ground truth\u2019"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-4993","authenticated-orcid":false,"given":"Vivek Y","family":"Reddy","sequence":"first","affiliation":[{"name":"Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , PO Box 1030, NewYork, NY 10029, USA"},{"name":"Department of Cardiology, Homolka Hospital , Roentgenova 37\/2, Prague 5 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-5935","authenticated-orcid":false,"given":"Melissa H","family":"Kong","sequence":"additional","affiliation":[{"name":"Ablacon Inc. ,Wheat Ridge, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Petru","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Homolka Hospital , Roentgenova 37\/2, Prague 5 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Maan","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , PO Box 1030, NewYork, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1620-3924","authenticated-orcid":false,"given":"Moritoshi","family":"Funasako","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Homolka Hospital , Roentgenova 37\/2, Prague 5 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-0673","authenticated-orcid":false,"given":"Kentaro","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Homolka Hospital , Roentgenova 37\/2, Prague 5 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-1778","authenticated-orcid":false,"given":"Peter","family":"Ruppersberg","sequence":"additional","affiliation":[{"name":"Ablacon Inc. ,Wheat Ridge, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Dukkipati","sequence":"additional","affiliation":[{"name":"Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , PO Box 1030, NewYork, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-8165","authenticated-orcid":false,"given":"Petr","family":"Neuzil","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Homolka Hospital , Roentgenova 37\/2, Prague 5 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"2023111318073768800_euad308-B1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/CIRCEP.114.001672","article-title":"Five-year follow-up after catheter ablation of persistent atrial fibrillation using the stepwise approach and prognostic factors for success","volume":"8","author":"Schreiber","year":"2015","journal-title":"Circ Arrhythm 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