{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:37:32Z","timestamp":1789083452581,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Norwegian Research council, ProCardio"},{"name":"GENE POSITIVE"},{"name":"EMPATHY"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with mitral valve prolapse (MVP) have high risk of life-threatening ventricular arrhythmias (VAs). Data on the impact of exercise on arrhythmic risk in these patients are lacking. We explored whether lifetime exercise dose was associated with severe VA and with established risk factors in patients with MVP. Furthermore, we explored the circumstances at the VA event.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In this retrospective cohort study, we included patients with MVP and assessed lifetime exercise dose as metabolic equivalents of task (MET) hours\/week. Severe VA was defined as sustained ventricular tachycardia or fibrillation, aborted cardiac arrest, and appropriate shock by a primary preventive implantable cardioverter defibrillator. We included 136 MVP patients (48 years [interquartile range (IQR) 35\u201359], 61% female), and 17 (13%) had previous severe VA. The lifetime exercise dose did not differ in patients with and without severe VA (17\u2005MET\u2005h\/week [IQR 9\u201327] vs. 14\u2005MET\u2005h\/week [IQR 6\u201331], P = 0.34). Lifetime exercise dose &amp;gt; 9.6\u2005MET\u2005h\/week was a borderline significant marker for severe VA (OR 3.38, 95% CI 0.92\u201312.40, P = 0.07), while not when adjusted for age (OR 2.63, 95% CI 0.66\u201310.56, P = 0.17). Ventricular arrhythmia events occurred most frequently during wakeful rest (53%), followed by exercise (29%) and sleep (12%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We found no clear association between moderate lifetime exercise dose and severe VA in patients with MVP. We cannot exclude an upper threshold for safe levels of exercise. Further studies are needed to explore exercise and risk of severe VA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad309","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T16:25:59Z","timestamp":1697646359000},"source":"Crossref","is-referenced-by-count":9,"title":["Lifetime exercise dose and ventricular arrhythmias in patients with mitral valve prolapse"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-0884","authenticated-orcid":false,"given":"Christian K","family":"Five","sequence":"first","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina E","family":"Hasselberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-2441","authenticated-orcid":false,"given":"Linda T","family":"Aaserud","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-856X","authenticated-orcid":false,"given":"Anna Isotta","family":"Castrini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-8932","authenticated-orcid":false,"given":"Katarina","family":"Vlaisavljevic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-1117","authenticated-orcid":false,"given":"\u00d8yvind","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-9969","authenticated-orcid":false,"given":"Christine","family":"Rootwelt-Norberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-4568","authenticated-orcid":false,"given":"Eivind W","family":"Aabel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-0453","authenticated-orcid":false,"given":"Kristina H","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ProCardio Center for Innovation, Oslo University Hospital, Rikshospitalet , PO Box 4950 Nydalen, 0424 Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , PO Box 1078 Blindern, 0316 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"2023103106265094300_euad309-B1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/europace\/euac125","article-title":"EHRA expert consensus statement on arrhythmic mitral 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