{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:40Z","timestamp":1787008780040,"version":"build-2736575974"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott Medical."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transvenous lead extraction (TLE) is performed using non-laser and laser techniques with overall high efficacy and safety. Variation in outcomes between the two approaches does exist with limited comparative evidence in the literature. We sought to compare non-laser and laser TLE in a meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We searched Medline, Embase, Scopus, ClinicalTrials.gov, and CENTRAL databases for TLE studies published between 1991 and 2021. From the included 68 studies, safety and efficacy data were carefully evaluated and extracted. Aggregated cases of outcomes were used to calculate odds ratio (OR), and pooled rates were synthesized from eligible studies to compare non-laser and laser techniques. Subgroup comparison of rotational tool and laser extraction was also performed. Non-laser in comparison with laser had lower procedural mortality (pooled rate 0% vs. 0.1%, P &amp;lt; 0.01), major complications (pooled rate 0.7% vs. 1.7%, P &amp;lt; 0.01), and superior vena cava (SVC) injury (pooled rate 0% vs. 0.5%, P &amp;lt; 0.001), with higher complete success (pooled rate 96.5% vs. 93.8%, P &amp;lt; 0.01). Non-laser comparatively to laser was more likely to achieve clinical [OR 2.16 (1.77\u20132.63), P &amp;lt; 0.01] and complete [OR 1.87 (1.69\u20132.08), P &amp;lt; 0.01] success, with a lower procedural mortality risk [OR 1.6 (1.02\u20132.5), P &amp;lt; 0.05]. In the subgroup analysis, rotational tool compared with laser achieved greater complete success (pooled rate 97.4% vs. 95%, P &amp;lt; 0.01) with lower SVC injury (pooled rate 0% vs. 0.7%, P &amp;lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non-laser TLE is associated with a better safety and efficacy profile when compared with laser methods. There is a greater risk of SVC injury associated with laser sheath extraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euad316","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T09:22:06Z","timestamp":1698312126000},"source":"Crossref","is-referenced-by-count":23,"title":["Comparison of non-laser and laser transvenous lead extraction: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-8826","authenticated-orcid":false,"given":"Zaki","family":"Akhtar","sequence":"first","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-2654","authenticated-orcid":false,"given":"Christos","family":"Kontogiannis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Georgiopoulos","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London , London , UK"},{"name":"Department of Clinical Therapeutics, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-1456","authenticated-orcid":false,"given":"Christoph T","family":"Starck","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-6440","authenticated-orcid":false,"given":"Lisa W M","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-8920","authenticated-orcid":false,"given":"Sun Y","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, San Joaquin General Hospital , French Camp, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-9851","authenticated-orcid":false,"given":"Byron K","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5948-6522","authenticated-orcid":false,"given":"Sreenivasa R K","family":"Seshasai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manav","family":"Sohal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-6420","authenticated-orcid":false,"given":"Mark M","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"2023111101533719400_euad316-B1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/europace\/euy050","article-title":"2018 EHRA expert consensus statement on lead extraction: recommendations on definitions, endpoints, research trial design, and data collection requirements for clinical scientific studies and registries: endorsed 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