{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:56:17Z","timestamp":1753876577435,"version":"3.41.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004610","name":"Science and Technology Planning Program of Guangdong Province","doi-asserted-by":"publisher","award":["2019B020230004"],"award-info":[{"award-number":["2019B020230004"]}],"id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["B2020181"],"award-info":[{"award-number":["B2020181"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Traditional ablation strategies including targeting the earliest Purkinje potential (PP) during left posterior fascicular (LPF) ventricular tachycardia (VT) or linear ablation at the middle segment of LPF during sinus rhythm are commonly used for the treatment of LPF-VT. Catheter ablation for LPF-VT targeting fragmented antegrade Purkinje (FAP) potential during sinus rhythm is a novel approach. We aimed to compare safety and efficacy of different ablation strategies (FAP ablation vs. traditional ablation) for the treatment of LPF-VT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients with electrocardiographically documented LPF-VT referred for catheter ablation received either FAP ablation approach or traditional ablation approach. Electrophysiological characteristics, procedural complications, and long-term clinical outcome were assessed. A total of 189 consecutive patients who underwent catheter ablation for LPF-VT were included. Fragmented antegrade Purkinje ablation was attempted in 95 patients, and traditional ablation was attempted in 94 patients. Acute ablation success with elimination of LPF-VT was achieved in all patients. Left posterior fascicular block occurred in 11 of 95 (11.6%) patients in the FAP group compared with 75 of 94 (79.8%) patients in the traditional group (P &amp;lt; 0.001). Fragmented antegrade Purkinje ablation was associated with significant shorter procedure time (94 \u00b1 26 vs. 117 \u00b1 23\u2005min, P = 0.03) and fewer radiofrequency energy applications (4.1 \u00b1 2.4 vs. 6.3 \u00b1 3.5, P = 0.003) compared with the traditional group. One complete atrioventricular block and one left bundle branch block were seen in the traditional group. Over mean follow-up of 65 months, 89 (93.7%) patients in the FAP group and 81 (86.2%) patients in the traditional group remained free of recurrent VT off antiarrhythmic drugs (P = 0.157).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Left posterior fascicular-ventricular tachycardia ablation utilizing FAP and traditional ablation approaches resulted in similar acute and long-term procedural outcomes. Serious His-Purkinje injury did occur infrequently during traditional ablation. The use of FAP ablation approach was associated with shorter procedure time and fewer radiofrequency energy applications, especially for non-inducible patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad339","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T16:54:02Z","timestamp":1700153642000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of strategies for catheter ablation of left posterior fascicular ventricular tachycardia"],"prefix":"10.1093","volume":"25","author":[{"given":"Hui-Qiang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-8276","authenticated-orcid":false,"given":"Wanwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sini","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No.167 Beilishi Rd. Xicheng District, 100037 Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Gang","family":"Guo","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No.167 Beilishi Rd. Xicheng District, 100037 Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Du","family":"Yang","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No.167 Beilishi Rd. Xicheng District, 100037 Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson J","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan Health System , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , No. 102 Zhongshan 2nd Rd, Yuexiu District, 510010 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4654-8587","authenticated-orcid":false,"given":"Jian","family":"Ma","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No.167 Beilishi Rd. 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