{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:45:36Z","timestamp":1778226336557,"version":"3.51.4"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T00:00:00Z","timestamp":1701561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Autothreshold algorithms enable remote monitoring of patients with conventional pacing, but there is limited information on their performance in left bundle branch pacing (LBBP). Our objective was to analyse the behaviour of the autothreshold algorithm in LBBP and compare it with conventional pacing and manual thresholds during initial device programming (acute phase), after 1\u20137 days (subacute), and 1\u20133 months later (chronic).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A prospective, non-randomized, single-centre comparative study was conducted. Consecutive patients with indication for cardiac pacing were enrolled. Implants were performed in the left bundle branch area or the right ventricle endocardium at the discretion of the operator. Left bundle branch pacing was determined according to published criteria. Autothreshold algorithm was activated in both groups whenever allowed by the device. Seventy-five patients were included, with 50 undergoing LBBP and 25 receiving conventional pacing. Activation of the autothreshold algorithm was more feasible in later phases, showing a favourable trend towards bipolar pacing. Failures in algorithm activation were primarily due to insufficient safety margins (82.8% in LBBP and 90% in conventional pacing). The remainder was attributed to atrial tachyarrhythmias (10.3% and 10%, respectively) and electrical noise (the remaining 6.9% in the LBBP group). In the LBBP group, there were not statistically significant differences between manual and automatic thresholds, and both remained stable during follow-up (mean increase of 0.50\u2005V).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The autothreshold algorithm is feasible in LBBP, with a favourable trend towards bipolar pacing. Automatic thresholds are similar to manual in patients with LBBP, and they remain stable during follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad359","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T05:07:43Z","timestamp":1701580063000},"source":"Crossref","is-referenced-by-count":6,"title":["Autothreshold algorithm feasibility and safety in left bundle branch pacing"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-1194","authenticated-orcid":false,"given":"Elena","family":"Sola-Garc\u00eda","sequence":"first","affiliation":[{"name":"Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2 , Granada 18014, Spain"},{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-6721","authenticated-orcid":false,"given":"Manuel","family":"Molina-Lerma","sequence":"additional","affiliation":[{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2, Granada 18014 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-898X","authenticated-orcid":false,"given":"Juan","family":"Jim\u00e9nez-J\u00e1imez","sequence":"additional","affiliation":[{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2, Granada 18014 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4686-5678","authenticated-orcid":false,"given":"Rosa","family":"Mac\u00edas-Ruiz","sequence":"additional","affiliation":[{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2, Granada 18014 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-2715","authenticated-orcid":false,"given":"Pablo J","family":"S\u00e1nchez-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2, Granada 18014 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-8809","authenticated-orcid":false,"given":"Luis","family":"Tercedor","sequence":"additional","affiliation":[{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2, Granada 18014 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-0749","authenticated-orcid":false,"given":"Miguel","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto de investigaci\u00f3n biosanitaria de Granada (FIBAO) , Edificio Licinio de la Fuente, Calle Dr. Azpitarte n\u00ba 4, Planta 5\u00aa, Granada 18012 , Spain"},{"name":"Arrhythmia Unit, Cardiology Department, Virgen de las Nieves University Hospital , Avenida de las Fuerzas Armadas n\u00b0 2, Granada 18014 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,3]]},"reference":[{"key":"2024013106581961600_euad359-B1","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart 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