{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:04:57Z","timestamp":1776139497120,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Data on repolarization parameters in cardiac resynchronization therapy (CRT) are scarce. We investigated the association of baseline T-wave area, with both clinical and echocardiographic outcomes of CRT in a large, multi-centre cohort of CRT recipients. Also, we evaluated the association between the baseline T-wave area and QRS area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In this retrospective study, 1355 consecutive CRT recipients were evaluated. Pre-implantation T-wave and QRS area were calculated from vectorcardiograms. Echocardiographic response was defined as a reduction of \u226515% in left ventricular end-systolic volume between 3 and 12 months after implantation. The clinical outcome was a combination of all-cause mortality, heart transplantation, and left ventricular assist device implantation. Left ventricular end-systolic volume reduction was largest in patients with QRS area \u2265 109\u2005\u03bcVs and T-wave area \u2265 66\u2005\u03bcVs compared with QRS area \u2265 109\u2005\u03bcVs and T-wave area &amp;lt; 66\u2005\u03bcVs (P = 0.004), QRS area &amp;lt; 109\u2005\u03bcVs and T-wave area \u2265 66\u2005\u03bcVs (P &amp;lt; 0.001) and QRS area &amp;lt; 109\u2005\u03bcVs and T-wave area &amp;lt; 66\u2005\u03bcVs (P &amp;lt; 0.001). Event-free survival rate was higher in the subgroup of patients with QRS area \u2265 109\u2005\u03bcVs and T-wave area \u2265 66\u2005\u03bcVs (n = 616, P &amp;lt; 0.001) and QRS area \u2265 109\u2005\u03bcVs and T-wave area &amp;lt; 66\u2005\u03bcVs (n = 100, P &amp;lt; 0.001) than the other subgroups. In the multivariate analysis, T-wave area remained associated with echocardiographic response (P = 0.008), but not with the clinical outcome (P = 0.143), when QRS area was included in the model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Baseline T-wave area has a significant association with both clinical and echocardiographic outcomes after CRT. The association of T-wave area with echocardiographic response is independent from QRS area; the association with clinical outcome, however, is not.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euad370","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T17:01:18Z","timestamp":1703264478000},"source":"Crossref","is-referenced-by-count":3,"title":["Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-8114","authenticated-orcid":false,"given":"Muhammet","family":"Dural","sequence":"first","affiliation":[{"name":"Department of Cardiology, Eski\u015fehir Osmangazi University Faculty of Medicine , Odunpazar\u0131, Eski\u015fehir 26040 , Turkey"},{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre+ , Maastricht 6202 , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Gerrits","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Utrecht , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-3161","authenticated-orcid":false,"given":"Fenna","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-2155","authenticated-orcid":false,"given":"Mathias","family":"Meine","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Utrecht , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-360X","authenticated-orcid":false,"given":"Alexander H","family":"Maass","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-070X","authenticated-orcid":false,"given":"Michiel","family":"Rienstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-9032","authenticated-orcid":false,"given":"Frits W","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-5964","authenticated-orcid":false,"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre+ , Maastricht 6202 , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-0727","authenticated-orcid":false,"given":"Antonius M W","family":"van Stipdonk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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