{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:38Z","timestamp":1787008778715,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Systolic blood pressure (SBP) drops recorded by 24-h ambulatory blood pressure (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed to increase BP (reassurance, education, and lifestyle measures plus pharmacological strategies) can reduce SBP drops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This was a multicentre, observational proof-of-concept study performed in patients with reflex syncope and\/or orthostatic intolerance and with SBP drops on a screening ABPM. Among 144 eligible patients, 111 underwent a second ABPM on average 2.5 months after start of treatment. Overall, mean 24-h SBP increased from 114.1 \u00b1 12.1 to 121.4 \u00b1 14.5\u2005mmHg (P &amp;lt; 0.0001). The number of SBP drops &amp;lt;90 and &amp;lt;100\u2005mmHg decreased by 61%, 46% during daytime, and by 48% and 37% during 24-h period, respectively (P &amp;lt; 0.0001 for all). The dose\u2013response relationship between difference in 24-h average SBP increase and reduction in number of SBP drops reached a plateau around \u223c15\u2005mmHg increase of 24-h SBP. The reduction in SBP drop rate was consistent and significant in patients who underwent deprescription of hypotensive medications (n = 44) and in patients who received BP-rising drugs (n = 67).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with reflex syncope and\/or orthostatic intolerance, an increase in average 24-h SBP, regardless of the implemented strategy, significantly reduced the number of SBP drops and symptom burden. A 13\u2005mmHg increase in 24-h SBP appears to represent the optimal goal for aborting the maximal number of SBP drops, representing a possible target for future interventions.<\/jats:p>\n                    <jats:p>ClincalTrials.gov identifier: NCT05729724<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euae026","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T19:48:41Z","timestamp":1706039321000},"source":"Crossref","is-referenced-by-count":23,"title":["Interventions aimed to increase average 24-h systolic blood pressure reduce blood pressure drops in patients with reflex syncope and orthostatic intolerance"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3386-6685","authenticated-orcid":false,"given":"Antonella","family":"Groppelli","sequence":"first","affiliation":[{"name":"Faint and Fall Research Centre, Department of Cardiology, IRCCS Istituto Auxologico Italiano, S. 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