{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:41:53Z","timestamp":1791348113321,"version":"4.3.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) detects myocardial scarring, a risk factor for ventricular arrhythmias (VAs) in hypertrophic cardiomyopathy (HCM). The LGE-CMR distinguishes core, borderzone (BZ) fibrosis, and BZ channels, crucial components of re-entry circuits. We studied how scar architecture affects inducibility and electrophysiological traits of VA in HCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We correlated scar composition with programmed ventricular stimulation-inducible VA features using LGE intensity maps. Thirty consecutive patients were enrolled. Thirteen (43%) were non-inducible, 6 (20%) had inducible non-sustained, and 11 (37%) had inducible sustained mono (MMVT)- or polymorphic VT\/VF (PVT\/VF). Of 17 induced VA, 13 (76%) were MMVT that either ended spontaneously, persisted as sustained monomorphic, or degenerated into PVT\/VF. Twenty-seven patients (90%) had LGE. Of these, 17 (57%) had non-sustained or sustained inducible VA. Scar mass significantly increased (P = 0.002) from non-inducible to inducible non-sustained and sustained VA patients in both the BZ and core components. Borderzone channels were found in 23%, 67%, and 91% of non-inducible, inducible non-sustained, and inducible sustained VA patients (P = 0.003). All 13 patients induced with MMVT or monomorphic-initiated PVT\/VF had LGE. The origin of 10\/13 of these VTs matched scar location, with 8\/10 of these LGE regions showing BZ channels. During follow-up (20 months, interquartile range: 7\u201337), one patient with BZ channels and inducible PVT had an ICD shock for VF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Scar architecture determines inducibility and electrophysiological traits of VA in HCM. Larger studies should explore the role of complex LGE patterns in refining risk assessment in HCM patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae050","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T10:06:02Z","timestamp":1708423562000},"source":"Crossref","is-referenced-by-count":15,"title":["Scar architecture affects the electrophysiological characteristics of induced ventricular arrhythmias in hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-7764","authenticated-orcid":false,"given":"Pietro","family":"Francia","sequence":"first","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"},{"name":"Cardiology Unit, Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, University Sapienza , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-9911","authenticated-orcid":false,"given":"Giulio","family":"Falasconi","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"},{"name":"IRCCS Humanitas Research Hospital , Cardiovascular Department, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7221-4829","authenticated-orcid":false,"given":"Diego","family":"Penela","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"},{"name":"IRCCS Humanitas Research Hospital , Cardiovascular Department, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-561X","authenticated-orcid":false,"given":"Daniel","family":"Viveros","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-5349","authenticated-orcid":false,"given":"Jos\u00e9","family":"Alderete","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-1507","authenticated-orcid":false,"given":"Andrea","family":"Saglietto","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"},{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u2018Citta della Salute e della Scienza Hospital , Turin , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Francisco","family":"Bellido","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-1190","authenticated-orcid":false,"given":"Julio","family":"Mart\u00ed-Almor","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center , C\/Vilana 12, 08022 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6157-058X","authenticated-orcid":false,"given":"Paula","family":"Franco-Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Arrhythmia Department, Teknon 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