{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:52:07Z","timestamp":1784130727208,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Data on safety outcomes of left atrial appendage occlusion (LAAO) in elderly patients are limited. This study aimed to compare the outcomes of LAAO between octogenarians (age 80\u201389) and nonagenarians (age \u226590) vs. younger patients (age \u226479).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study using the National Inpatient Sample database to identify patients hospitalized for LAAO from 2016 to 2020 and to compare in-hospital safety outcomes in octogenarians and nonagenarians vs. younger patients. The primary outcome was a composite of in-hospital all-cause mortality or stroke. Secondary outcomes included procedural complications, length of stay (LOS), and total costs. Outcomes were determined using logistic regression models. Among 84 140 patients hospitalized for LAAO, 32.9% were octogenarians, 2.8% were nonagenarians, and 64.3% were \u226479 years of age. Over the study period, the volume of LAAO increased in all age groups (all Ptrend &amp;lt; 0.01). After adjustment for clinical and demographic factors, octogenarians and nonagenarians had similar odds of in-hospital all-cause mortality or stroke [adjusted odds ratio (aOR) 1.41, 95% confidence interval (CI) 0.93\u20132.13 for octogenarians; aOR 1.69, 95% CI 0.67\u20133.92 for nonagenarians], cardiac tamponade, acute kidney injury, major bleeding, and blood transfusion, in addition to similar LOS and total costs compared with younger patients (all P &amp;gt; 0.05). However, octogenarians and nonagenarians had higher odds of vascular complications compared with younger patients (aOR 1.47, 95% CI 1.08\u20131.99 for octogenarians; aOR 1.60, 95% CI 1.18\u20132.97 for nonagenarians).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Octogenarians and nonagenarians undergoing LAAO have a similar safety profile compared with clinically similar younger patients except for higher odds of vascular complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae055","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T22:53:37Z","timestamp":1708642417000},"source":"Crossref","is-referenced-by-count":9,"title":["In-hospital safety outcomes of left atrial appendage occlusion in octogenarians and nonagenarians"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-7835","authenticated-orcid":false,"given":"Mahmoud","family":"Ismayl","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7825-8252","authenticated-orcid":false,"given":"Hasaan","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Creighton University School of Medicine , Omaha, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-7837","authenticated-orcid":false,"given":"Andrew M","family":"Goldsweig","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Baystate Medical Center , Springfield, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-6879","authenticated-orcid":false,"given":"James V","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First Street SW, Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"2024032717500382800_euae055-B1","doi-asserted-by":"crossref","first-page":"e006350","DOI":"10.1161\/CIRCEP.118.006350","article-title":"Lifetime risk of atrial fibrillation by race and socioeconomic status: ARIC study (Atherosclerosis Risk in 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endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA)","volume":"25","author":"Savelieva","year":"2023","journal-title":"Europace"},{"key":"2024032717500382800_euae055-B5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart 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advanced age with procedural complications and in-hospital outcomes from left atrial appendage occlusion device implantation in patients with atrial fibrillation: insights from the National Inpatient Sample of 36,065 procedures","volume":"65","author":"Munir","year":"2022","journal-title":"J Interv Card Electrophysiol"},{"key":"2024032717500382800_euae055-B23","doi-asserted-by":"crossref","first-page":"e008418","DOI":"10.1161\/CIRCOUTCOMES.121.008418","article-title":"Indications for left atrial appendage occlusion in the United States and associated in-hospital outcomes: results from the NCDR LAAO registry","volume":"15","author":"Daimee","year":"2022","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2024032717500382800_euae055-B24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.amjcard.2023.08.177","article-title":"Age-based trends in the outcomes of percutaneous left atrial appendage occlusion: insights from a real-world 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