{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:21:06Z","timestamp":1793845266473,"version":"4.6.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200347"],"award-info":[{"award-number":["82200347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570309"],"award-info":[{"award-number":["81570309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004862","name":"Zhejiang Medical Science and Technology Program","doi-asserted-by":"publisher","award":["2022RC224"],"award-info":[{"award-number":["2022RC224"]}],"id":[{"id":"10.13039\/501100004862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Catheter ablation of ventricular tachycardia (VT) improves VT-free survival in \u2018classic\u2019 arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to investigate electrophysiological features and ablation outcomes in patients with ARVC and biventricular (BiV) involvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We assembled a retrospective cohort of definite ARVC cases with sustained VTs. Patients were divided into the BiV (BiV involvement) group and the right ventricular (RV) (isolated RV involvement) group based on the left ventricular systolic function detected by cardiac magnetic resonance. All patients underwent electrophysiological mapping and VT ablation. Acute complete success was non-inducibility of any sustained VT, and the primary endpoint was VT recurrence. Ninety-eight patients (36 \u00b1 14 years; 87% male) were enrolled, including 50 in the BiV group and 48 in the RV group. Biventricular involvement was associated with faster clinical VTs, a higher VT inducibility, and more extensive arrhythmogenic substrates (all P &amp;lt; 0.05). Left-sided VTs were observed in 20% of the BiV group cases and correlated with significantly reduced left ventricular systolic function. Catheter ablation achieved similar acute efficacy between these two groups, whereas the presence of left-sided VTs increased acute ablation failure (40 vs. 5%, P = 0.012). Over 51 \u00b1 34 months [median, 48 (22\u201383) months] of follow-up, cumulative VT-free survival was 52% in the BiV group and 58% in the RV group (P = 0.353). A multivariate analysis showed that younger age, lower RV ejection fraction (RVEF), and non-acute complete ablation success were associated with VT recurrence in the BiV group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Biventricular involvement implied a worse arrhythmic phenotype and increased the risk of left-sided VTs, while catheter ablation maintained its efficacy for VT control in this population. Younger age, lower RVEF, and non-acute complete success predicted VT recurrence after ablation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae059","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T06:39:59Z","timestamp":1709102399000},"source":"Crossref","is-referenced-by-count":11,"title":["Catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy and biventricular involvement"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-4215","authenticated-orcid":false,"given":"Lishui","family":"Shen","sequence":"first","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"},{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University , Shanghai 200072 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-2741","authenticated-orcid":false,"given":"Shangyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"},{"name":"Department of Cardiology, The First Hospital of Hebei Medical University , Shijiazhuang 050031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1501-2209","authenticated-orcid":false,"given":"Zhenhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Lai","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7876-8691","authenticated-orcid":false,"given":"Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai 200127 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2867-411X","authenticated-orcid":false,"given":"Lihui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-4323","authenticated-orcid":false,"given":"Yan","family":"Yao","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 North Lishi Road, Xicheng District , Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"2024032716151874900_euae059-B1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.CIR.94.5.983","article-title":"Arrhythmogenic right ventricular cardiomyopathy. 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