{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:38:39Z","timestamp":1792640319375,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health-Ricerca Corrente to Centro Cardiologico Monzino IRCCS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Women have been historically underrepresented in implantable cardioverter-defibrillator (ICD) trials. No data on sex differences regarding subcutaneous ICDs (S-ICD) carriers have been described. Aim of our study was to investigate sex-related differences among unselected S-ICD recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Consecutive patients enrolled in the multicentre, international i-SUSI registry were analysed. Comparisons between sexes were performed using a 1:1 propensity matching adjusted analysis for age, body mass index (BMI), left ventricular function, and substrate. The primary outcome was the rate of appropriate shocks during follow-up. Inappropriate shocks and other device-related complications were deemed secondary outcomes. A total of 1698 patients were extracted from the i-SUSI registry; 399 (23.5%) were females. After propensity matching, two cohorts of 374 patients presenting similar baseline characteristics were analysed. Despite similar periprocedural characteristics and a matched BMI, women resulted at lower risk of conversion failure as per PRAETORIAN score (73.4% vs. 81.3%, P = 0.049). Over a median follow-up time of 26.5 [12.7\u201342.5] months, appropriate shocks were more common in the male cohort (rate\/year 3.4% vs. 1.7%; log-rank P = 0.049), while no significant differences in device-related complications (rate\/year: 6.3% vs. 5.8%; log-rank P = 0.595) and inappropriate shocks (rate\/year: 4.3% vs. 3.1%; log-rank P = 0.375) were observed. After controlling for confounders, sex remained significantly associated with the primary outcome (aHR 1.648; CI 0.999\u20132.655, P = 0.048), while not resulting predictor of inappropriate shocks and device-related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a propensity-matched cohort of S-ICD recipients, women are less likely to experience appropriate ICD therapy, while not showing higher risk of device-related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT0473876.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euae115","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T07:43:50Z","timestamp":1714549430000},"source":"Crossref","is-referenced-by-count":5,"title":["Sex differences among subcutaneous implantable cardioverter-defibrillator recipients: a propensity-matched, multicentre, international analysis from the i-SUSI project"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-3380","authenticated-orcid":false,"given":"Marco","family":"Schiavone","sequence":"first","affiliation":[{"name":"Department of Clinical Electrophysiology & Cardiac Pacing, Centro Cardiologico Monzino, IRCCS , Via Carlo Parea 4, 20138 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-070X","authenticated-orcid":false,"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins University , Baltimore , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-9750","authenticated-orcid":false,"given":"Julia","family":"Vogler","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck , Lubeck , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-6548","authenticated-orcid":false,"given":"Paolo","family":"Compagnucci","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, University Hospital \u2018Ospedali Riuniti\u2019 , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-2656","authenticated-orcid":false,"given":"Mikael","family":"Laredo","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re and Sorbonne Universit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-2947","authenticated-orcid":false,"given":"Alexander","family":"Breitenstein","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, University Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gulletta","sequence":"additional","affiliation":[{"name":"Arrhythmology and Electrophysiology Unit, San Raffaele Hospital, IRCCS , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-8488","authenticated-orcid":false,"given":"Martin","family":"Martinek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 2\/Cardiology, Ordensklinikum Linz Elisabethinen , Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-8954","authenticated-orcid":false,"given":"Lukas","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, St. George Klinik Asklepios , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-535X","authenticated-orcid":false,"given":"Fabrizio","family":"Tundo","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology & Cardiac Pacing, Centro Cardiologico Monzino, IRCCS , Via Carlo Parea 4, 20138 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-6218","authenticated-orcid":false,"given":"Pietro","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Cardiology Unit, \u2018Card. 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