{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:20:42Z","timestamp":1787563242489,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize the diagnosis, frequency, and procedural implications of septal venous channel perforation during left bundle branch area pacing (LBBAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>All consecutive patients undergoing LBBAP over an 8-month period were prospectively studied. During lead placement, obligatory septal contrast injection was performed twice, at initiation (implant entry zone) and at completion (fixation zone). An intuitive fluoroscopic schema using orthogonal views (left anterior oblique\/right anterior oblique) and familiar landmarks is described. Using this, we resolved zonal distribution (I\u2013VI) of lead position on the ventricular septum and its angulation (post-fixation angle \u03b8). Subjects with and without septal venous channel perforation were compared. Sixty-one patients {male 57.3%, median age [interquartile range (IQR)] 69.5 [62.5\u201374.5] years} were enrolled. Septal venous channel perforation was observed in eight (13.1%) patients [male 28.5%, median age (IQR) 64 (50\u201375) years]. They had higher frequency of (i) right-sided implant (25% vs. 1.9%, P = 0.04), (ii) fixation in zone III at the mid-superior septum (75% vs. 28.3%, P = 0.04), (iii) steeper angle of fixation\u2014median \u03b8 (IQR) [19 (10\u201330)\u00b0 vs. 5 (4\u201319)\u00b0, P = 0.01], and (iv) longer median penetrated-lead length (IQR) [13 (10\u201314.8) vs. 10 (8.5\u201312.5) mm, P = 0.03]. Coronary sinus drainage of contrast was noted in five (62.5%) patients. Abnormal impedance drops during implantation (12.5% vs. 5.7%, P = NS) were not significantly different.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When evaluated systematically, septal venous channel perforation may be encountered commonly after LBBAP. The fiducial reference framework described using fluoroscopic imaging identified salient associated findings. This may be addressed with lead repositioning to a more inferior location and is not associated with adverse consequence acutely or in early follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euae124","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T12:44:56Z","timestamp":1714826696000},"source":"Crossref","is-referenced-by-count":19,"title":["Septal venous channel perforation during left bundle branch area pacing: a prospective study"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-4536","authenticated-orcid":false,"given":"Anindya","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology and Pacing, Arrhythmia Heart Failure Academy, The Madras Medical Mission , 4-A, Dr. JJ Nagar, Mogappair, Chennai, Tamil Nadu 600037 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-1743","authenticated-orcid":false,"given":"Anbarasan","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology and Pacing, Arrhythmia Heart Failure Academy, The Madras Medical Mission , 4-A, Dr. JJ Nagar, Mogappair, Chennai, Tamil Nadu 600037 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-209X","authenticated-orcid":false,"given":"Chenni S","family":"Sriram","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Sub-section of Electrophysiology, Children\u2019s Hospital of Michigan and Detroit Medical Center , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-2322","authenticated-orcid":false,"given":"Kothandam","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Institute of Cardiovascular Diseases, The Madras Medical Mission , Chennai, Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3493-2100","authenticated-orcid":false,"given":"Gaurav A","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Care, Section of Cardiology, University of Chicago Pritzker School of Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulhas M","family":"Pandurangi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology and Pacing, Arrhythmia Heart Failure Academy, The Madras Medical Mission , 4-A, Dr. JJ Nagar, Mogappair, Chennai, Tamil Nadu 600037 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"2024062813273696000_euae124-B1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.hrthm.2022.01.032","article-title":"Complications with left bundle branch area pacing","volume":"19","author":"Burri","year":"2022","journal-title":"Heart Rhythm"},{"key":"2024062813273696000_euae124-B2","doi-asserted-by":"crossref","first-page":"ytab049","DOI":"10.1093\/ehjcr\/ytab049","article-title":"Visualization of a septal perforator branch vein and coronary sinus during left bundle pacing implant","volume":"5","author":"Molina-Lerma","year":"2021","journal-title":"Eur Heart J Case Rep"},{"key":"2024062813273696000_euae124-B3","doi-asserted-by":"crossref","first-page":"101622","DOI":"10.1016\/j.jaccas.2022.08.037","article-title":"Coronary venous visualization during deep septal lead placement: an unexpected finding","volume":"4","author":"Batul","year":"2022","journal-title":"JACC Case Rep"},{"key":"2024062813273696000_euae124-B4","first-page":"507","article-title":"Septal coronary vein infringement during LBBAP","volume":"66","author":"O'Neill","year":"2023","journal-title":"J Interv Card Electrophysiol"},{"key":"2024062813273696000_euae124-B5","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/joa3.12942","article-title":"Breaching septal veins while attempting left bundle branch area pacing. 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