{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:15:36Z","timestamp":1773958536774,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NNF Young Investigator Awards 2021","award":["NNF21OC0066480"],"award-info":[{"award-number":["NNF21OC0066480"]}]},{"DOI":"10.13039\/501100011958","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["102900011B"],"award-info":[{"award-number":["102900011B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NNF Tandem Programme","award":["NNF18OC0031634"],"award-info":[{"award-number":["NNF18OC0031634"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulmonary vein isolation (PVI) is the corner stone of modern rhythm control strategies in patients with atrial fibrillation (AF). Sleep-disordered breathing (SDB) is prevalent in more than 50% of patients undergoing AF ablation, and studies have indicated a greater recurrence rate after PVI in patients with SDB. Herein, we study the effect of catheter-based PVI on AF in a pig model for SDB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In 11 sedated spontaneously breathing pigs, obstructive apnoeas were simulated by 75\u2005s of intermittent negative upper airway pressure (INAP) applied by a negative pressure device connected to the endotracheal tube. Intermittent negative upper airway pressures were performed before and after PVI. AF-inducibility and atrial effective refractory periods (aERPs) were determined before and during INAP by programmed atrial stimulation. Pulmonary vein isolation prolonged the aERP by 48 \u00b1 27\u2005ms in the right atrium (RA) (P &amp;lt; 0.0001) and by 40 \u00b1 34\u2005ms in the left atrium (LA) (P = 0.0004). Following PVI, AF-inducibility dropped from 28 \u00b1 26% to 0% (P = 0.0009). Intermittent negative upper airway pressure was associated with a transient aERP-shortening (\u0394aERP) in both atria, which was not prevented by PVI (INAP indued \u0394aERP after PVI in the RA: \u221257 \u00b1 34\u2005ms, P = 0.0002; in the LA: \u221242 \u00b1 24\u2005ms, P &amp;lt; 0.0001). Intermittent negative upper airway pressure was associated with a transient increase in AF-inducibility (from 28 \u00b1 26% to 69 \u00b1 21%; P = 0.0008), which was not attenuated by PVI [INAP-associated AF-inducibility after PVI: 58 \u00b1 33% (P = 0.5)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Transient atrial arrhythmogenic changes related to acute obstructive respiratory events are not prevented by electrical isolation of the pulmonary veins, which partially explains the increased AF recurrence in patients with SDB after PVI procedures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae132","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T18:26:28Z","timestamp":1715970388000},"source":"Crossref","is-referenced-by-count":2,"title":["Catheter-based pulmonary vein isolation fails to prevent transient atrial arrhythmogenic changes related to acute obstructive respiratory events in a porcine model"],"prefix":"10.1093","volume":"26","author":[{"given":"Julie","family":"Norup Hertel","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-1131","authenticated-orcid":false,"given":"Jonas L","family":"Isaksen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0046-8731","authenticated-orcid":false,"given":"Kezia","family":"Jerltorp","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-7147","authenticated-orcid":false,"given":"Sarah","family":"Dalgas Nissen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malthe","family":"Hansen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-0902","authenticated-orcid":false,"given":"Arnela","family":"Saljic","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"},{"name":"West German Heart and Vascular Center, Institute of Pharmacology, University Duisburg-Essen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-4130","authenticated-orcid":false,"given":"Benedikt","family":"Linz","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-8329","authenticated-orcid":false,"given":"Stefan","family":"Sattler","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ye","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5715-0581","authenticated-orcid":false,"given":"Jakob","family":"Overgaard Larsen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1227-5113","authenticated-orcid":false,"given":"Malene","family":"N\u00f8rregaard","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-6193","authenticated-orcid":false,"given":"Sevasti-Maria","family":"Chaldoupi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre , Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-306X","authenticated-orcid":false,"given":"Uffe","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital Roskilde , Roskilde , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-4373","authenticated-orcid":false,"given":"Martin","family":"Manninger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre , Maastricht , The Netherlands"},{"name":"Division of Cardiology, Department of Internal Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-360X","authenticated-orcid":false,"given":"Thomas","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-0824","authenticated-orcid":false,"given":"Dominik","family":"Linz","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen , Denmark"},{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht 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