{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:37Z","timestamp":1787008777195,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key Technology R&D Program of Ningbo","award":["2022Z149"],"award-info":[{"award-number":["2022Z149"]}]},{"name":"Key Technology R&D Program of Ningbo","award":["2023Z188"],"award-info":[{"award-number":["2023Z188"]}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LGJ20H20001"],"award-info":[{"award-number":["LGJ20H20001"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Radiofrequency ablation is used as a first-line therapy for accessory pathways (APs). However, data regarding the effects of pulsed field ablation (PFA) on APs are limited. We sought to evaluate the acute procedural and 6-month success and safety of PFA in a cohort of patients with APs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A focal contact force\u2013sensing PFA catheter was used for patients with APs. Pulsed field ablation generator generated a bipolar and biphasic waveform (\u00b11000\u2005V) with a duration of 100\u2005ms from the tip of the PFA catheter. A 100% acute procedural success was achieved in 10 conscious patients with APs (7 left anterolateral, 2 left inferolateral, and 1 right posteroseptal APs) including 6 (60%) patients after an initial application. The average total ablation time was 6.3 \u00b1 4.9\u2005s for 4.7 \u00b1 1.8 ablation sites (ASs), including 3.1 \u00b1 2.4\u2005s at targets and 3.2 \u00b1 2.9\u2005s at 3.2 \u00b1 2 bolus ASs. The mean skin-to-skin time was 59.3 \u00b1 15.5\u2005min, and PFA catheter dwell time was 29.4 \u00b1 7.8\u2005min. One patient encountered transient sinus arrest during PFA due to parasympathetic overexcitation. Sinus rhythm was restored in all patients without any significant adverse events during the short-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pulsed field ablation of APs was feasible, effective, and safe. Its efficiency was remarkable for its ultrarapid termination of AP conduction. Further studies are warranted to prove whether utilization of PFA with current parameters can extend to manifold AP ablation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euae139","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T12:06:48Z","timestamp":1716811608000},"source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of pulsed field ablation for accessory pathways: a pilot study"],"prefix":"10.1093","volume":"26","author":[{"given":"Caijie","family":"Shen","sequence":"first","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Jia","sequence":"additional","affiliation":[{"name":"Health Science Center, Ningbo University , Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-7180","authenticated-orcid":false,"given":"Yibo","family":"Yu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-7974","authenticated-orcid":false,"given":"Xianfeng","family":"Du","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-9452","authenticated-orcid":false,"given":"Guohua","family":"Fu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipu","family":"Yu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5750-909X","authenticated-orcid":false,"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-5656","authenticated-orcid":false,"given":"He","family":"Jin","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Gao","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-3878","authenticated-orcid":false,"given":"Binhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiating","family":"Dai","sequence":"additional","affiliation":[{"name":"Health Science Center, Ningbo University , Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-332X","authenticated-orcid":false,"given":"Renyuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-6831","authenticated-orcid":false,"given":"Huimin","family":"Chu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, The First Affiliated Hospital of Ningbo University , 59th Liuting Street, Haishu district, Ningbo 315000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"2024073112131704000_euae139-B1","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1016\/j.hrthm.2015.09.019","article-title":"2015 ACC\/AHA\/HRS guideline for the management of adult patients with supraventricular tachycardia: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"13","author":"Page","year":"2015","journal-title":"Heart Rhythm"},{"key":"2024073112131704000_euae139-B2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/eurheartj\/ehz467","article-title":"2019 ESC guidelines for the management of patients with supraventricular tachycardia: the task force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)","volume":"41","author":"Brugada","year":"2020","journal-title":"Eur Heart J"},{"key":"2024073112131704000_euae139-B3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jce.16113","article-title":"Very high-power short-duration catheter ablation for treatment of cardiac arrhythmias: insights from the FAST and FURIOUS study series","volume":"35","author":"Heeger","year":"2024","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2024073112131704000_euae139-B4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCEP.108.803650","article-title":"Novel contact force sensor incorporated in irrigated radiofrequency ablation catheter predicts lesion size and incidence of steam pop and thrombus","volume":"1","author":"Yokoyama","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112131704000_euae139-B5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10840-021-01064-1","article-title":"Redo accessory pathway ablation in the pediatric population","volume":"63","author":"Corcia","year":"2022","journal-title":"J Interv Card Electrophysiol"},{"key":"2024073112131704000_euae139-B6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.hrthm.2019.08.013","article-title":"Catheter ablation in children and patients with congenital heart disease: review of 1021 procedures at a high-volume single center in Japan","volume":"17","author":"Kato","year":"2020","journal-title":"Heart Rhythm"},{"key":"2024073112131704000_euae139-B7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10840-020-00823-w","article-title":"Ablation of manifest septal accessory pathways: a single-center experience","volume":"61","author":"Brown","year":"2021","journal-title":"J Interv Card Electrophysiol"},{"key":"2024073112131704000_euae139-B8","doi-asserted-by":"crossref","first-page":"e15493","DOI":"10.14814\/phy2.15493","article-title":"Human cardiomyocytes are more susceptible to irreversible electroporation by pulsed electric field than human esophageal cells","volume":"10","author":"Casciola","year":"2022","journal-title":"Physiol Rep"},{"key":"2024073112131704000_euae139-B9","doi-asserted-by":"crossref","first-page":"euad257","DOI":"10.1093\/europace\/euad257","article-title":"Determinants of acute irreversible electroporation lesion characteristics after pulsed field ablation: the role of voltage, contact, and adipose interference","volume":"25","author":"Gasperetti","year":"2023","journal-title":"Europace"},{"key":"2024073112131704000_euae139-B10","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jacep.2021.02.014","article-title":"Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PFECAT, and PFECAT II","volume":"7","author":"Reddy","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112131704000_euae139-B11","doi-asserted-by":"crossref","first-page":"e010168","DOI":"10.1161\/CIRCEP.121.010168","article-title":"First-in-human experience and acute procedural outcomes using a novel pulsed field ablation system: the PULSED AF pilot trial","volume":"15","author":"Verma","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112131704000_euae139-B12","article-title":"Outcomes of focal pulsed field ablation for paroxysmal supraventricular tachycardia","volume":"17","author":"Caijie","year":"2024","journal-title":"Can J Cardial"},{"key":"2024073112131704000_euae139-B13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jacep.2023.08.030","article-title":"The safety and feasibility of pulsed-field ablation in atrioventricular nodal reentrant tachycardia: first-in-human pilot trial","volume":"10","author":"Zeng","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112131704000_euae139-B14","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ccep.2020.09.003","article-title":"Methodology of typical accessory pathway catheter ablation","volume":"12","author":"Romero","year":"2020","journal-title":"Card Electrophysiol Clin"},{"key":"2024073112131704000_euae139-B15","first-page":"e012026","article-title":"Effects of contact force on lesion size during pulsed field catheter ablation: histochemical characterization of ventricular lesion boundaries","volume":"28","author":"Nakagawa","year":"2023","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112131704000_euae139-B16","first-page":"222","article-title":"Effects of pulse field ablation on the atrioventricular conduction in canine","volume":"11","author":"Caijie","year":"2023","journal-title":"Chin J Heart Rhythm"},{"key":"2024073112131704000_euae139-B17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12872-022-02544-6","article-title":"Conventional fluoroscopy-guided versus zero-fluoroscopy catheter ablation of supraventricular tachycardias","volume":"22","author":"Proli\u010d Kalin\u0161ek","year":"2022","journal-title":"BMC Cardiovasc Disord"},{"key":"2024073112131704000_euae139-B18","doi-asserted-by":"crossref","first-page":"e010661","DOI":"10.1161\/CIRCEP.121.010661","article-title":"Time course of irreversible electroporation lesion development through short- and long-term follow-up in pulsed-field ablation-treated hearts","volume":"15","author":"Grimaldi","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112131704000_euae139-B19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00392-018-1367-3","article-title":"Remaining challenges in catheter ablation of accessory pathways: rare entity of coronary sinus diverticulum-associated pathways","volume":"108","author":"Leitz","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2024073112131704000_euae139-B20","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.hrthm.2019.01.012","article-title":"Pulsed electric fields for cardiac ablation and beyond: a state-of-the-art review","volume":"16","author":"Maor","year":"2019","journal-title":"Heart Rhythm"},{"key":"2024073112131704000_euae139-B21","doi-asserted-by":"crossref","first-page":"e005207","DOI":"10.1161\/CIRCEP.116.005207","article-title":"Experimental, pathologic, and clinical findings of radiofrequency catheter ablation of para-Hisian region from the right ventricle in dogs and humans","volume":"10","author":"Xue","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112131704000_euae139-B22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jacep.2020.10.004","article-title":"Reversible atrioventricular conduction impairment following bipolar nanosecond electroporation of the interventricular septum","volume":"7","author":"van Zyl","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112131704000_euae139-B23","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jacep.2023.05.005","article-title":"Thermal profiles for focal pulsed electric field ablation","volume":"9","author":"Verma","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112131704000_euae139-B24","doi-asserted-by":"crossref","first-page":"e012018","DOI":"10.1161\/CIRCEP.123.012018","article-title":"Reversible pulsed electrical fields as an in vivo tool to study cardiac electrophysiology: the advent of pulsed field mapping","volume":"16","author":"Koruth","year":"2023","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112131704000_euae139-B25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10840-018-0339-x","article-title":"Preventing the risk of coronary injury in posteroseptal accessory pathway ablation in children: different strategies and advantages of fluoroscopy integrated 3D-mapping system (CARTO-UNIVU\u2122)","volume":"52","author":"Alazard","year":"2018","journal-title":"J Interv Card Electrophysiol"},{"key":"2024073112131704000_euae139-B26","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s10840-023-01675-w","article-title":"Coronary sinus ablations in pediatric patients with supraventricular arrhythmias","volume":"66","author":"Kamali","year":"2023","journal-title":"J Interv Card Electrophysiol"},{"key":"2024073112131704000_euae139-B27","first-page":"e234405","article-title":"Coronary artery spasm during pulsed field vs radiofrequency catheter ablation of the mitral isthmus","volume":"29","author":"Zhang","year":"2023","journal-title":"JAMA Cardiol"},{"key":"2024073112131704000_euae139-B28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1253\/circj.66.696","article-title":"Pharmacological and electrophysiological characterization of junctional rhythm during radiofrequency catheter ablation of the atrioventricular node: possible involvement of neurotransmitters from autonomic nervous system","volume":"66","author":"Sugiyama","year":"2002","journal-title":"Circ J"},{"key":"2024073112131704000_euae139-B29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.hroo.2021.10.004","article-title":"Safety and efficacy aspects of pulsed field ablation catheters as a function of electrode proximity to blood and energy delivery method","volume":"2","author":"Belalcazar","year":"2021","journal-title":"Heart Rhythm"},{"key":"2024073112131704000_euae139-B30","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jacep.2022.04.017","article-title":"Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation","volume":"8","author":"Stojadinovi\u0107","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112131704000_euae139-B31","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/europace\/euac050","article-title":"Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF)","volume":"24","author":"Ekanem","year":"2022","journal-title":"Europace"},{"key":"2024073112131704000_euae139-B32","doi-asserted-by":"crossref","first-page":"euad151","DOI":"10.1093\/europace\/euad151","article-title":"Silent cerebral lesions following catheter ablation for atrial fibrillation: a state-of-the-art review","volume":"25","author":"Calvert","year":"2023","journal-title":"Europace"},{"key":"2024073112131704000_euae139-B33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jacep.2021.02.014","article-title":"Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II","volume":"7","author":"Reddy","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112131704000_euae139-B34","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.hrthm.2021.02.015","article-title":"Absence of (sub-)acute cerebral events or lesions after electroporation ablation in the left-sided canine heart","volume":"18","author":"Neven","year":"2021","journal-title":"Heart Rhythm"},{"key":"2024073112131704000_euae139-B35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/europace\/euaa243","article-title":"In vivo analysis of the origin and characteristics of gaseous microemboli during catheter-mediated irreversible electroporation","volume":"23","author":"Groen","year":"2021","journal-title":"Europace"},{"key":"2024073112131704000_euae139-B36","doi-asserted-by":"crossref","first-page":"e0122166","DOI":"10.1371\/journal.pone.0122166","article-title":"Size distribution of air bubbles entering the brain during cardiac surgery","volume":"10","author":"Chung","year":"2015","journal-title":"PLoS One"},{"key":"2024073112131704000_euae139-B37","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/europace\/eut254","article-title":"Catheter ablation of an anteroseptal accessory pathway guided by contact force monitoring technology and precise electroanatomical mapping","volume":"16","author":"Gulletta","year":"2014","journal-title":"Europace"},{"key":"2024073112131704000_euae139-B38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1475-925X-10-102","article-title":"High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction","volume":"10","author":"Arena","year":"2021","journal-title":"Biomed Eng Online"}],"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euae139\/57927799\/euae139.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/26\/7\/euae139\/58391172\/euae139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/26\/7\/euae139\/58391172\/euae139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T21:58:39Z","timestamp":1722463119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euae139\/7683186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euae139","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,5,27]]},"article-number":"euae139"}}