{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:26:44Z","timestamp":1792787204373,"version":"4.5.0"},"reference-count":154,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Significant changes in tricuspid regurgitation (TR) and mitral regurgitation (MR) post-cardiac implantable electronic devices (CIEDs) are increasingly recognized. However, uncertainty remains as to whether the risk of CIED-associated TR and MR differs with right ventricular pacing (RVP) via CIED with trans-tricuspid RV leads, compared with cardiac resynchronization therapy (CRT), conduction system pacing (CSP), and leadless pacing (LP). The study aims to synthesize extant data on risk and prognosis of significant post-CIED TR and MR across pacing strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We searched PubMed, EMBASE, and Cochrane Library databases published until 31 October 2023. Significant post-CIED TR and MR were defined as \u2265 moderate. Fifty-seven TR studies (n = 13 723 patients) and 90 MR studies (n = 14 387 patients) were included. For all CIED, the risk of post-CIED TR increased [pooled odds ratio (OR) = 2.46 and 95% CI = 1.88\u20133.22], while the risk of post-CIED MR reduced (OR = 0.74, 95% CI = 0.58\u20130.94) after 12 and 6 months of median follow-up, respectively. Right ventricular pacing via CIED with trans-tricuspid RV leads was associated with increased risk of post-CIED TR (OR = 4.54, 95% CI = 3.14\u20136.57) and post-CIED MR (OR = 2.24, 95% CI = 1.18\u20134.26). Binarily, CSP did not alter TR risk (OR = 0.37, 95% CI = 0.13\u20131.02), but significantly reduced MR (OR = 0.15, 95% CI = 0.03\u20130.62). Cardiac resynchronization therapy did not significantly change TR risk (OR = 1.09, 95% CI = 0.55\u20132.17), but significantly reduced MR with prevalence pre-CRT of 43%, decreasing post-CRT to 22% (OR = 0.49, 95% CI = 0.40\u20130.61). There was no significant association of LP with post-CIED TR (OR = 1.15, 95% CI = 0.83\u20131.59) or MR (OR = 1.31, 95% CI = 0.72\u20132.39). Cardiac implantable electronic device\u2013associated TR was independently predictive of all-cause mortality [pooled hazard ratio (HR) = 1.64, 95% CI = 1.40\u20131.90] after median of 53 months. Mitral regurgitation persisting post-CRT independently predicted all-cause mortality (HR = 2.00, 95% CI = 1.57\u20132.55) after 38 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that, when possible, adoption of pacing strategies that avoid isolated trans-tricuspid RV leads may be beneficial in preventing incident or deteriorating atrioventricular valvular regurgitation and might reduce mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euae143","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T17:36:11Z","timestamp":1716917771000},"source":"Crossref","is-referenced-by-count":26,"title":["Evolution and prognosis of tricuspid and mitral regurgitation following cardiac implantable electronic devices: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-3320","authenticated-orcid":false,"given":"Matthew F","family":"Yuyun","sequence":"first","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System , 1400 VFW Parkway, West Roxbury, MA 02132 , USA"},{"name":"Department of Medicine, Harvard Medical School , 25 Shattuck St, Boston, MA 02115 , USA"},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine , 72 E Concord St, Boston, MA 02118 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-4896","authenticated-orcid":false,"given":"Jacob","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System , 1400 VFW Parkway, West Roxbury, MA 02132 , USA"},{"name":"Department of Medicine, VA Providence Healthcare System , 830 Chalkstone Ave, Providence, RI 02908 , USA"},{"name":"Department of Medicine, Brown University , 1 Prospect Street, Providence, RI 02912 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebhat A","family":"Erqou","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Providence Healthcare System , 830 Chalkstone Ave, Providence, RI 02908 , USA"},{"name":"Department of Medicine, Brown University , 1 Prospect Street, Providence, RI 02912 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-9136","authenticated-orcid":false,"given":"Scott","family":"Kinlay","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System , 1400 VFW Parkway, West Roxbury, MA 02132 , USA"},{"name":"Department of Medicine, Harvard Medical School , 25 Shattuck St, Boston, MA 02115 , USA"},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine , 72 E Concord St, Boston, MA 02118 , USA"},{"name":"Department of Medicine, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-1617","authenticated-orcid":false,"given":"Justin B","family":"Echouffo-Tcheugui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine , 733 N Broadway, Baltimore, MD 21205 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-2213","authenticated-orcid":false,"given":"Adelqui O","family":"Peralta","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System , 1400 VFW Parkway, West Roxbury, MA 02132 , USA"},{"name":"Department of Medicine, Harvard Medical School , 25 Shattuck St, Boston, MA 02115 , USA"},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine , 72 E Concord St, Boston, MA 02118 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System , 1400 VFW Parkway, West Roxbury, MA 02132 , USA"},{"name":"Department of Medicine, Harvard Medical School , 25 Shattuck St, Boston, MA 02115 , USA"},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine , 72 E Concord St, Boston, MA 02118 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-8084","authenticated-orcid":false,"given":"William E","family":"Boden","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System , 1400 VFW Parkway, West Roxbury, MA 02132 , USA"},{"name":"Department of Medicine, Harvard Medical School , 25 Shattuck St, Boston, MA 02115 , USA"},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine , 72 E Concord St, Boston, MA 02118 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-5834","authenticated-orcid":false,"given":"Hirad","family":"Yarmohammadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University \u00a0 Irving Medical Center, 177 Fort Washington Avenue, New York, NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5213-1227","authenticated-orcid":false,"given":"David T","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School , 25 Shattuck St, Boston, MA 02115 , USA"},{"name":"Department of Medicine, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagmeet P","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard 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