{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:25:16Z","timestamp":1789791916695,"version":"4.0.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We aimed to assess the acute and midterm efficacy of premature ventricular contraction (PVC) ablation guided by multielectrode and point-by-point (PbP) mapping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This is a retrospective, international multicentre study of consecutive patients referred for PVC ablation in 10 hospital centres from January 2017 to December 2021. Based on the mapping approach, two cohorts were identified: the \u2018Multipolar group\u2019, where a dedicated high-density mapping catheter was employed, and the \u2018PbP group\u2019, where mapping was performed with the ablation catheter. Procedural endpoints, safety, and acute (procedural) and midterm efficacies were assessed. Of the 698 patients included in this study, 592 received activation mapping [46% males, median age of 55 (41\u201365) years]\u2014248 patients in the Multipolar group and 344 patients in the PbP group. A higher number of activation points [432 (217\u2013843) vs. 95 (42\u2013185), P &amp;lt; 0.001], reduced mapping time (40 \u00b1 38 vs. 61 \u00b1 50\u2005min, P &amp;lt; 0.001), and shorter procedure time (124 \u00b1 60 vs. 143 \u00b1 63\u2005min, P &amp;lt; 0.001) were reported in the Multipolar group. Both groups had high acute success rates (84.7% with Multipolar mapping vs. 81.3% with PbP mapping, P = 0.63), as well as midterm efficacy (83.4% vs. 77.4%, P = 0.08), with no significant differences in the risk of adverse events (6.0% vs. 3.5%, P = 0.24). However, for left-sided PVC ablation specifically, there was a higher midterm efficacy in the Multipolar group (80.7% vs. 69.5%, P = 0.04), with multipolar mapping being an independent predictor of success [adjusted OR = 2.231 (95% CI, 1.476\u20135.108), P = 0.02].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The acute and midterm efficacies of PVC ablation are high with both multipolar and PbP mapping, although the former allows for quicker procedures and may potentially improve the outcomes of left-sided PVC ablation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae148","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T21:03:58Z","timestamp":1717016638000},"source":"Crossref","is-referenced-by-count":4,"title":["Real-world assessment of multipolar and point-by-point mapping for premature ventricular contraction ablation"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-767X","authenticated-orcid":false,"given":"Pedro A","family":"Sousa","sequence":"first","affiliation":[{"name":"Pacing & Electrophysiology Unit, Cardiology Department, Coimbra\u2019s Hospital and University Center , Morada: Praceta Prof Mota Pinto, 3000-075 Coimbra , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-8384","authenticated-orcid":false,"given":"Johanna","family":"Tonko","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sussex Cardiac Centre , Brighton , UK"},{"name":"Institute of Cardiovascular Science, University College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-5877","authenticated-orcid":false,"given":"Dagmara","family":"Dilling-Boer","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hartcentrum Hasselt , Hasselt , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-3767","authenticated-orcid":false,"given":"S\u00e9rgio","family":"Barra","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital da Luz Arr\u00e1bida , V. N. Gaia , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-9899","authenticated-orcid":false,"given":"Anna-Sophie","family":"Eberl","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-5238","authenticated-orcid":false,"given":"Borka","family":"Pezo","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Centre Zagreb , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-4631","authenticated-orcid":false,"given":"Nuno","family":"Cortez-Dias","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Santa Maria University Hospital, Lisbon Academic Medical Center , Lisbon , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Khoueiry","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinique Saint Pierre , Perpignan , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-9780","authenticated-orcid":false,"given":"Paulo","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro Hospitalar de Entre Douro e Vouga , Santa Maria da Feira , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-9321","authenticated-orcid":false,"given":"Mois\u00e9s","family":"Rodr\u00edguez-Ma\u00f1ero","sequence":"additional","affiliation":[{"name":"Cardiology Department , University Center Hospital of Santiago, Santiago de Compostela , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-4042","authenticated-orcid":false,"given":"Ana","family":"Lebreiro","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Center of S\u00e3o Jo\u00e3o , Porto , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-8026","authenticated-orcid":false,"given":"Mariana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Biosense Webster , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-3449","authenticated-orcid":false,"given":"Lu\u00eds","family":"Puga","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro Hospitalar de Entre Douro e Vouga , Santa Maria da Feira , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-5493","authenticated-orcid":false,"given":"Daniel","family":"Scherr","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-4353","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Ant\u00f3nio","sequence":"additional","affiliation":[{"name":"Pacing & Electrophysiology Unit, Cardiology Department, Coimbra\u2019s Hospital and University Center , Morada: Praceta Prof Mota Pinto, 3000-075 Coimbra , Portugal"},{"name":"Faculty of Medicine, ICBR, University of Coimbra , Coimbra , Portugal"},{"name":"Cardiology Department, Santa Marta Hospital , Lisboa , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-9497","authenticated-orcid":false,"given":"Afonso","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Santa Maria University Hospital, Lisbon Academic Medical Center , Lisbon , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-0257","authenticated-orcid":false,"given":"Carolina","family":"Saleiro","sequence":"additional","affiliation":[{"name":"Pacing & Electrophysiology Unit, Cardiology Department, Coimbra\u2019s Hospital and University Center , Morada: Praceta Prof Mota Pinto, 3000-075 Coimbra , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2650-0036","authenticated-orcid":false,"given":"Philippe","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinique Saint Pierre , Perpignan , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3852-3314","authenticated-orcid":false,"given":"Luis","family":"Ad\u00e3o","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Center of S\u00e3o Jo\u00e3o , Porto , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2782-8214","authenticated-orcid":false,"given":"Joao","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Santa Maria University Hospital, Lisbon Academic Medical Center , Lisbon , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Elvas","sequence":"additional","affiliation":[{"name":"Pacing & Electrophysiology Unit, Cardiology Department, Coimbra\u2019s Hospital and University Center , Morada: Praceta Prof Mota Pinto, 3000-075 Coimbra , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-8354","authenticated-orcid":false,"given":"M\u00e1rio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Marta Hospital , Lisboa , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-3064","authenticated-orcid":false,"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Pacing & Electrophysiology Unit, Cardiology Department, Coimbra\u2019s Hospital and University Center , Morada: Praceta Prof Mota Pinto, 3000-075 Coimbra , Portugal"},{"name":"Faculty of Medicine, ICBR, University of Coimbra , Coimbra , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2245-7285","authenticated-orcid":false,"given":"John","family":"Silberbauer","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sussex Cardiac Centre , Brighton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"2024062813382693800_euae148-B1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jacc.2015.04.062","article-title":"Ventricular ectopy as a predictor of heart failure and death","volume":"66","author":"Dukes","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2024062813382693800_euae148-B2","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"2024062813382693800_euae148-B3","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/j.hrthm.2014.07.024","article-title":"EHRA\/HRS\/APHRS expert consensus on ventricular arrhythmias","volume":"11","author":"Pedersen","year":"2014","journal-title":"Heart Rhythm"},{"key":"2024062813382693800_euae148-B4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jacep.2018.11.019","article-title":"Multielectrode mapping and pattern matching recognition for left premature ventricular contraction ablation","volume":"5","author":"Sousa","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"key":"2024062813382693800_euae148-B5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.repc.2020.08.009","article-title":"Pattern matching filter and multielectrode mapping catheter\u2014a new approach for complex premature ventricular contraction ablation","volume":"40","author":"Sousa","year":"2021","journal-title":"Rev Port Cardiol (Engl Ed)"},{"key":"2024062813382693800_euae148-B6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijcard.2023.04.044","article-title":"Multielectrode mapping for premature ventricular contraction ablation\u2014a prospective, multicenter study","volume":"383","author":"Sousa","year":"2023","journal-title":"Int J Cardiol"},{"key":"2024062813382693800_euae148-B7","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.hrthm.2021.05.023","article-title":"Impact of a predefined pacemapping protocol use for ablation of infrequent premature ventricular complexes: a prospective, multicenter study","volume":"18","author":"J\u00e1uregui","year":"2021","journal-title":"Heart Rhythm"},{"key":"2024062813382693800_euae148-B8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/CIRCEP.113.000833","article-title":"Novel algorithmic methods in mapping of atrial and ventricular tachycardia","volume":"7","author":"El Haddad","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024062813382693800_euae148-B9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.hrthm.2021.12.035","article-title":"How to use bipolar and unipolar electrograms for selecting successful ablation sites of ventricular premature contractions","volume":"19","author":"Higuchi","year":"2022","journal-title":"Heart Rhythm"},{"key":"2024062813382693800_euae148-B10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jacc.2013.06.012","article-title":"Neurohormonal, structural, and functional recovery pattern after premature ventricular complex ablation is independent of structural heart disease status in patients with depressed left ventricular ejection fraction: a prospective multicenter study","volume":"62","author":"Penela","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2024062813382693800_euae148-B11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/CIRCEP.114.002737","article-title":"High-resolution mapping of scar-related atrial arrhythmias using smaller electrodes with closer interelectrode spacing","volume":"8","author":"Anter","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024062813382693800_euae148-B12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/s12872-020-01747-z","article-title":"Multipolar mapping for catheter ablation of premature ventricular complexes originating from papillary muscles in the structurally normal heart: a case series","volume":"20","author":"Cai","year":"2020","journal-title":"BMC Cardiovasc Disord"},{"key":"2024062813382693800_euae148-B13","first-page":"440","article-title":"A novel multielectrode catheter for high-density ventricular mapping: electrogram characterization and utility for scar mapping","volume":"22","author":"Barkagan","year":"2020","journal-title":"Europace"},{"key":"2024062813382693800_euae148-B14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jacep.2015.04.005","article-title":"Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes","volume":"1","author":"Latchamsetty","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"key":"2024062813382693800_euae148-B15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00392-016-1022-9","article-title":"Safety and efficacy in ablation of premature ventricular contraction: data from the German ablation registry","volume":"106","author":"Fichtner","year":"2017","journal-title":"Clin Res Cardiol"},{"key":"2024062813382693800_euae148-B16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/heartjnl-2013-305175","article-title":"Beneficial effects of catheter ablation of frequent premature ventricular complexes on left ventricular function","volume":"100","author":"Zang","year":"2014","journal-title":"Heart"},{"key":"2024062813382693800_euae148-B17","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/jce.12762","article-title":"Safety and clinical outcome of catheter ablation of ventricular arrhythmias using contact force sensing: consecutive case series","volume":"26","author":"Hendriks","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2024062813382693800_euae148-B18","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1111\/jce.14120","article-title":"Ablation using 3D maps adjusted for spatial displacement of premature ventricular complexes relative to sinus beats: improving precision by correcting for the shift","volume":"30","author":"Steyers","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2024062813382693800_euae148-B19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/europace\/euaa013","article-title":"Premature ventricular contractions cause a position shift in 3D mapping systems: analysis, quantification, and correction by hybrid activation mapping","volume":"22","author":"De Potter","year":"2020","journal-title":"Europace"}],"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euae148\/58028711\/euae148.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/26\/6\/euae148\/58340915\/euae148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/26\/6\/euae148\/58340915\/euae148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:44:14Z","timestamp":1719582254000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euae148\/7685608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euae148","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,5,31]]},"article-number":"euae148"}}