{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:06:05Z","timestamp":1791014765122,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Subcutaneous implantable cardioverter-defibrillators (S-ICDs) offer potentially distinct advantages over transvenous defibrillator systems. Recent randomized trials showed significantly lower lead failure rates than transvenous ICD. Still, S-ICDs remain associated with the risk of inappropriate shocks (IAS). While previous studies have reported varying causes of IAS, this study explores a rare cause of IAS, referred to as \u2018sense-B-noise.\u2019 It was recently described in case series, but its incidence has not been studied in a large cohort of S-ICD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We retrospectively reviewed data from patients implanted with S-ICD models 1010, A209, and A219 between October 2009 and July 2023 across nine centres in Europe and the USA. The analysis concentrated on determining the incidence and understanding the implications of sense-B-noise events. Sense-B-noise represents a rare manifestation of distinct electrogram abnormalities within the primary and alternate sensing vectors. Data were collected from medical records, device telemetry, and manufacturer reports for investigation. This registry is registered on clinicaltrials.gov (NCT05713708). Subcutaneous implantable cardioverter-defibrillator devices of the 1158 patients were analysed. The median follow-up time for all patients was 46 (IQR 23\u201364) months. In 107 patients (9.2%) \u22651 IAS was observed during follow-up. Sense-B-noise failure was diagnosed in six (0.5 and 5.6% of all IAS) patients, in all patients, the diagnosis was made after an IAS episode. Median lead dwell time in the affected patients was 23 (2\u201370) months. To resolve the sense-B-noise defect, in three patients reprogramming to the secondary vector was undertaken, and two patients underwent system removal with subsequent S-ICD reimplantation due to low amplitude in the secondary vector. In one patient, the secondary vector was initially programmed, and subsequently, an S-ICD system exchange was performed due to T-wave-oversensing IAS episodes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This multicentre analysis\u2019 findings shed light on a rare but clinically highly significant adverse event in S-ICD therapy. To our knowledge, we provide the first systematic multicentre analysis investigating the incidence of sense-B-noise. Due to being difficult to diagnose and limited options for resolution, management of sense-B-noise is challenging. Complete system exchange may be the only option for some patients. Educating healthcare providers involved in S-ICD patient care is crucial for ensuring accurate diagnosis and effective management of sense-B-noise issues.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae161","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T21:19:35Z","timestamp":1718054375000},"source":"Crossref","is-referenced-by-count":2,"title":["Incidence, implications, and management of sense-B-noise failure in subcutaneous cardioverter-defibrillator patients: insights from a large multicentre registry"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-8946","authenticated-orcid":false,"given":"Jonas","family":"W\u00f6rmann","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Heart Center at the University of Cologne , Kerpener Str. 62, 50937 Cologne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-6548","authenticated-orcid":false,"given":"Marc","family":"Strik","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, service de Cardiologie-\u00e9lectrophysiologie et stimulation cardiaque, INSERM, U 1045 , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stjepan","family":"Jurisic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2004-8015","authenticated-orcid":false,"given":"Kara","family":"Stout","sequence":"additional","affiliation":[{"name":"Cardiology, VCU Health Pauley Heart Center , Richmond, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-1940","authenticated-orcid":false,"given":"Mohamed","family":"Elrefai","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Research Department, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-1341","authenticated-orcid":false,"given":"Nina","family":"Becher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/Luebeck , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1768-1968","authenticated-orcid":false,"given":"Beat","family":"Schaer","sequence":"additional","affiliation":[{"name":"Cardiology, University Hospital Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-0727","authenticated-orcid":false,"given":"Antonius","family":"van Stipdonk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-6547","authenticated-orcid":false,"given":"Neil T","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, The Essex Cardiothoracic Centre , Basildon , UK"},{"name":"Circulatory Health Research Group, Medical Technology Research Centre, School of Medicine, Anglia Ruskin University , Chelmsford CM1 1SQ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-2967","authenticated-orcid":false,"given":"Sylvain","family":"Ploux","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, service de Cardiologie-\u00e9lectrophysiologie et stimulation cardiaque, INSERM, U 1045 , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-2947","authenticated-orcid":false,"given":"Alexander","family":"Breitenstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3397-0535","authenticated-orcid":false,"given":"Jordana","family":"Kron","sequence":"additional","affiliation":[{"name":"Cardiology, VCU Health Pauley Heart Center , Richmond, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-6401","authenticated-orcid":false,"given":"Paul R","family":"Roberts","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Research Department, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-0621","authenticated-orcid":false,"given":"Tobias","family":"Toennis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/Luebeck , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-0824","authenticated-orcid":false,"given":"Dominik","family":"Linz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-2494","authenticated-orcid":false,"given":"Rajdip","family":"Dulai","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, The Essex Cardiothoracic Centre , Basildon , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-2832","authenticated-orcid":false,"given":"Julia","family":"Hermes-Laufer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-0962","authenticated-orcid":false,"given":"Jay","family":"Koneru","sequence":"additional","affiliation":[{"name":"Cardiology, VCU Health Pauley Heart Center , Richmond, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-1308","authenticated-orcid":false,"given":"\u00d6mer","family":"Erk\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-6971","authenticated-orcid":false,"given":"Sebastian","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center at the University of Cologne , Kerpener Str. 62, 50937 Cologne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-4887","authenticated-orcid":false,"given":"Jan-Hendrik","family":"van den Bruck","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center at the University of Cologne , Kerpener Str. 62, 50937 Cologne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-3295","authenticated-orcid":false,"given":"Jan-Hendrik","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center at the University of 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