{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:34:35Z","timestamp":1791516875171,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Prior case series showed promising results for cardioneuroablation in patients with vagally induced atrioventricular blocks (VAVBs). We aimed to examine the acute procedural characteristics and intermediate-term outcomes of electroanatomical-guided cardioneuroablation (EACNA) in patients with VAVB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This international multicentre retrospective registry included data collected from 20 centres. Patients presenting with symptomatic paroxysmal or persistent VAVB were included in the study. All patients underwent EACNA. Procedural success was defined by the acute reversal of atrioventricular blocks (AVBs) and complete abolition of atropine response. The primary outcome was occurrence of syncope and daytime second- or advanced-degree AVB on serial prolonged electrocardiogram monitoring during follow-up. A total of 130 patients underwent EACNA. Acute procedural success was achieved in 96.2% of the cases. During a median follow-up of 300 days (150, 496), the primary outcome occurred in 17\/125 (14%) cases with acute procedural success (recurrence of AVB in 9 and new syncope in 8 cases). Operator experience and use of extracardiac vagal stimulation were similar for patients with and without primary outcomes. A history of atrial fibrillation, hypertension, and coronary artery disease was associated with a higher primary outcome occurrence. Only four patients with primary outcome required pacemaker placement during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This is the largest multicentre study demonstrating the feasibility of EACNA with encouraging intermediate-term outcomes in selected patients with VAVB. Studies investigating the effect on burden of daytime symptoms caused by the AVB are required to confirm these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae164","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T23:01:17Z","timestamp":1719961277000},"source":"Crossref","is-referenced-by-count":23,"title":["Procedural and Intermediate-term Results of the Electroanatomical-guided Cardioneuroablation for the Treatment of Supra-Hisian Second- or Advanced-degree Atrioventricular Block: the PIRECNA multicentre registry"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8061-9660","authenticated-orcid":false,"given":"Tolga","family":"Aksu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Yeditepe University Hospital , Icerenkoy Mah. Hastahane Sok. 4, 34752, Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-4898","authenticated-orcid":false,"given":"Roman","family":"Piotrowski","sequence":"additional","affiliation":[{"name":"Centre of Postgraduate Medical Education, Department of Cardiology, Grochowski Hospital , 01-809, Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-1303","authenticated-orcid":false,"given":"Roderick","family":"Tung","sequence":"additional","affiliation":[{"name":"The University of Arizona College of Medicine-Phoenix, Department of Cardiology, Banner University Medical Center , Phoenix, AZ 85004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-114X","authenticated-orcid":false,"given":"Tom","family":"De Potter","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, OLV Hospital , Aalst, 9300 , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-2006","authenticated-orcid":false,"given":"Timothy M","family":"Markman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0806-1786","authenticated-orcid":false,"given":"Jeanne","family":"du Fay de Lavallaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel , Petersgraben 4, 4031 Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roin","family":"Rekvava","sequence":"additional","affiliation":[{"name":"Department of Rhythm Management and Electrophysiology, American Hospital Tbilisi , Tbilisi 01102 , Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-4286","authenticated-orcid":false,"given":"Daniel","family":"Alyesh","sequence":"additional","affiliation":[{"name":"South Denver Cardiology Associates , Littleton, CO 80120, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-688X","authenticated-orcid":false,"given":"Jacqueline E","family":"Joza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, McGill University , Montreal, QC, H3A 0G4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-0557","authenticated-orcid":false,"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel , Petersgraben 4, 4031 Basel , 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