{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:28:06Z","timestamp":1784154486448,"version":"3.55.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Ministry of Health and Social Affairs"},{"DOI":"10.13039\/501100006636","name":"Swedish Research Council for Health, Working Life and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2017-06088"],"award-info":[{"award-number":["2017-06088"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["899871"],"award-info":[{"award-number":["899871"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) has been associated with functional impairment. However, the role exerted by AF on the long-term trajectories of functional mobility remains to be elucidated. This study aimed to evaluate the impact of AF on functional mobility by tracing walking speed (WS) trajectories over 15 years of follow-up in a population-based cohort of individuals aged 60+ years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This population-based cohort study included 3141 community-dwelling participants (mean age 73.7 years; 63.6% women) from the Swedish National Study on Aging and Care in Kungsholmen, who were regularly examined from 2001\u20132004 to 2016\u20132019. Functional mobility was assessed by measuring WS in a standardized way. The association between AF and WS trajectories was assessed by multivariable joint models accounting for the longitudinal dropouts due to death. Stratified analyses by demographic and clinical factors were performed. The effect-modifying role of oral anticoagulant therapy (OAC), incident heart failure (HF), and incident stroke was finally investigated. At baseline, 285 (9.1%) participants were ascertained to have AF. A faster annual WS decline was observed in persons with AF than in non-AF peers (adjusted \u03b2 coefficient per year = \u22120.011, 95% confidence interval: \u22120.016 to \u22120.005). Incident HF and stroke were associated with greater WS decline in participants with AF. OAC use was not associated with a slower functional decline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Atrial fibrillation is associated with a faster physical function decline in older individuals. Incident HF and stroke possibly accelerate WS decline over time in AF participants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae173","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:18:46Z","timestamp":1719235126000},"source":"Crossref","is-referenced-by-count":12,"title":["Atrial fibrillation accelerates functional decline in older adults: a 15-year follow-up population-based study"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-7393","authenticated-orcid":false,"given":"Chukwuma","family":"Okoye","sequence":"first","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm University , Tomtebodav\u00e4gen 18a, 171 65 Solna , Sweden"},{"name":"Department of Medicine and Surgery, University of Milan-Bicocca , Via Cadore 48, 20900 Monza \u00a0 Italy"},{"name":"Acute Geriatric Unit, IRCCS Foundation 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Hong","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK"},{"name":"Liverpool John Moores University , Liverpool , UK"},{"name":"Liverpool Heart and Chest Hospital , Liverpool , UK"},{"name":"Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University , Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-0947","authenticated-orcid":false,"given":"Giuseppe","family":"Bellelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milan-Bicocca , Via Cadore 48, 20900 Monza \u00a0 Italy"},{"name":"Acute Geriatric Unit, IRCCS Foundation San Gerardo dei Tintori , Monza, Via Pergolesi 33, 20900 Monza , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5819-8724","authenticated-orcid":false,"given":"Anna-Karin","family":"Welmer","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm University , Tomtebodav\u00e4gen 18a, 171 65 Solna , Sweden"},{"name":"Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , Stockholm , Sweden"},{"name":"Stockholm Gerontology Research Centre , Stockholm , Sweden"},{"name":"Women\u2019s Health and Allied Health Professionals Theme, Medical Unit Medical Psychology, Karolinska University Hospital , Stockholm , 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