{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:53:33Z","timestamp":1791726813640,"version":"4.3.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012070","name":"Dinova EP Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulsed field ablation (PFA) is an emerging non-thermal ablative modality demonstrating considerable promise for catheter ablation of atrial fibrillation (AF). However, these PFA trials have almost universally included only Caucasian populations, with little data on its effect on other races\/ethnicities. The PLEASE-AF trial sought to study the 12-month efficacy and the safety of a multi-electrode hexaspline PFA catheter in treating a predominantly Asian\/Chinese population of patients with drug-refractory paroxysmal AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients underwent pulmonary vein (PV) isolation (PVI) by delivering different pulse intensities at the PV ostium (1800 V) and atrium (2000 V). Acute success was defined as no PV potentials and entrance\/exit conduction block of all PVs after a 20-min waiting period. Follow-up at 3, 6, and 12 months included 12-lead electrocardiogram and 24-h Holter examinations. The primary efficacy endpoint was 12-month freedom from any atrial arrhythmias lasting at least 30 s. The cohort included 143 patients from 12 hospitals treated by 28 operators: age 60.2 \u00b1 10.0 years, 65.7% male, Asian\/Chinese 100%, and left atrial diameter 36.6 \u00b1 4.9 mm. All PVs (565\/565, 100%) were successfully isolated. The total procedure, catheter dwell, total PFA application, and total fluoroscopy times were 123.5 \u00b1 38.8 min, 63.0 \u00b1 30.7 min, 169.7 \u00b1 34.6 s, and 27.3 \u00b1 10.1 min, respectively. The primary endpoint was observed in 124 of 143 patients (86.7%). One patient (0.7%) developed a small pericardial effusion 1-month post-procedure, not requiring intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The novel hexaspline PFA catheter demonstrated universal acute PVI with an excellent safety profile and promising 12-month freedom from recurrent atrial arrhythmias in an Asian\/Chinese population with paroxysmal AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration<\/jats:title>\n                  <jats:p>ClinicalTrials.gov Identifier: NCT05114954<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae174","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:34:00Z","timestamp":1719236040000},"source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of a novel hexaspline pulsed field ablation system in patients with paroxysmal atrial fibrillation: the <i>PLEASE-AF<\/i> study"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0364-8736","authenticated-orcid":false,"given":"Zulu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, General Hospital of Northern Theater Command , Wenhua Road No. 83, Shenhe District, 110016 Shenyang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-0556","authenticated-orcid":false,"given":"Min","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-4993","authenticated-orcid":false,"given":"Vivek Y","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-6831","authenticated-orcid":false,"given":"Huimin","family":"Chu","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Ningbo First Hospital, The First Affiliated Hospital of Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Chaoyang Hospital Affiliated to Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-0014","authenticated-orcid":false,"given":"Yumei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial People\u2019s Hospital , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital , Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-6868","authenticated-orcid":false,"given":"Shaowen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai First People\u2019s Hospital , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-1246","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School , Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3569-5856","authenticated-orcid":false,"given":"Zhihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Third Xiangya Hospital of Central South University , Changsha , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-0573","authenticated-orcid":false,"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuzhou Central Hospital , Xuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiangxi Provincial People\u2019s Hospital , Nanchang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-9305","authenticated-orcid":false,"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai East Hospital , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital of Northern Theater Command , Wenhua Road No. 83, Shenhe District, 110016 Shenyang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-0567","authenticated-orcid":false,"given":"Ming","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital of Northern Theater Command , Wenhua Road No. 83, Shenhe District, 110016 Shenyang , 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