{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:39:51Z","timestamp":1791319191186,"version":"4.3.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Metabolic and Cardiovascular Research","award":["LX22NPO5104"],"award-info":[{"award-number":["LX22NPO5104"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["00023001"],"award-info":[{"award-number":["00023001"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IKEM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>A pulsed electric field (PF) energy source is a novel potential option for catheter ablation of ventricular arrhythmias (VAs) as it can create deeper lesions, particularly in scarred tissue. However, very limited data exist on its efficacy and safety. This prospective observational study reports the initial experience with VA ablation using focal PF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study population consisted of 44 patients (16 women, aged 61 \u00b1 14years) with either frequent ventricular premature complexes (VPCs, 48%) or scar-related ventricular tachycardia (VT, 52%). Ablation was performed using an irrigated 4 mm tip catheter and a commercially available PF generator. On average, 16 \u00b1 15 PF applications (25 A) were delivered per patient. Acute success was achieved in 84% of patients as assessed by elimination of VPC or reaching non-inducibility of VT. In three cases (7%), a transient conduction system block was observed during PF applications remotely from the septum. Root analysis revealed that this event was caused by current leakage from the proximal shaft electrodes in contact with the basal interventricular septum. Acute elimination of VPC was achieved in 81% patients and non-inducibility of VT in 83% patients. At the 3-month follow-up, persistent suppression of the VPC was confirmed on Holter monitoring in 81% patients. In the VT group, the mean follow-up was 116 \u00b1 75 days and a total of 52% patients remained free of any VA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pulsed electric field catheter ablation of a broad spectrum of VA is feasible with acute high efficacy; however, the short-term follow-up is less satisfactory for patients with scar-related VT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae192","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T07:39:36Z","timestamp":1720683576000},"source":"Crossref","is-referenced-by-count":38,"title":["Efficacy and safety of focal pulsed-field ablation for ventricular arrhythmias: two-centre experience"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-0071","authenticated-orcid":false,"given":"Petr","family":"Peichl","sequence":"first","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-207X","authenticated-orcid":false,"given":"Alan","family":"Bulava","sequence":"additional","affiliation":[{"name":"\u010cesk\u00e9 Bud\u011bjovice Hospital and Faculty of Health and Social Sciences, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice , \u010cesk\u00e9 Bud\u011bjovice , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-5143","authenticated-orcid":false,"given":"Dan","family":"Wichterle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5106-4314","authenticated-orcid":false,"given":"Filip","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-5823","authenticated-orcid":false,"given":"Predrag","family":"Stojadinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9756-283X","authenticated-orcid":false,"given":"Eva","family":"Bori\u0161incov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-3545","authenticated-orcid":false,"given":"Peter","family":"\u0160tiavnick\u00fd","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-8672","authenticated-orcid":false,"given":"Jana","family":"Ha\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-6182","authenticated-orcid":false,"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IKEM , V\u00edde\u0148sk\u00e1 1958\/9, Praha 4, Prague 140 21 , Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"2024073112210391500_euae192-B1","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"2024073112210391500_euae192-B2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10840-022-01287-w","article-title":"A systematic review and meta-analysis comparing radiofrequency catheter ablation with medical therapy for ventricular tachycardia in patients with ischemic and non-ischemic cardiomyopathies","volume":"66","author":"Ravi","year":"2023","journal-title":"J Interv Card Electrophysiol"},{"key":"2024073112210391500_euae192-B3","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1161\/CIRCULATIONAHA.122.059598","article-title":"Does timing of ventricular tachycardia ablation affect prognosis in patients with an implantable cardioverter defibrillator? Results from the multicenter randomized PARTITA trial","volume":"145","author":"Della Bella","year":"2022","journal-title":"Circulation"},{"key":"2024073112210391500_euae192-B4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jacep.2019.08.015","article-title":"Temperature-controlled radiofrequency ablation using irrigated catheters: maximizing ventricular lesion dimensions while reducing steam-pop formation","volume":"6","author":"Leshem","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112210391500_euae192-B5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jacep.2023.09.015","article-title":"Efficacy of pulsed field vs radiofrequency for the reablation of chronic radiofrequency ablation substrate: redo pulsed field ablation","volume":"10","author":"Younis","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112210391500_euae192-B6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/europace\/euz341","article-title":"Endocardial ventricular pulsed field ablation: a proof-of-concept preclinical evaluation","volume":"22","author":"Koruth","year":"2020","journal-title":"Europace"},{"key":"2024073112210391500_euae192-B7","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jacep.2022.06.002","article-title":"Bipolar electroporation across the interventricular septum: electrophysiological, imaging, and histopathological characteristics","volume":"8","author":"Zyl M van","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112210391500_euae192-B8","doi-asserted-by":"crossref","first-page":"euad147","DOI":"10.1093\/europace\/euad147","article-title":"Pulsed field ablation using focal contact force-sensing catheters for treatment of atrial fibrillation: acute and 90-day invasive remapping results","volume":"25","author":"Ani\u0107","year":"2023","journal-title":"Europace"},{"key":"2024073112210391500_euae192-B9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.hrcr.2023.05.019","article-title":"Focal pulsed field electroporation of left ventricular premature contractions after failed radiofrequency ablation","volume":"9","author":"Hansen","year":"2023","journal-title":"HeartRhythm Case Rep"},{"key":"2024073112210391500_euae192-B10","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/jce.16195","article-title":"Ablation of epicardial ventricular focus through coronary sinus using pulsed-field ablation. A case report","volume":"35","author":"Mestrovic","year":"2024","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2024073112210391500_euae192-B11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.hroo.2023.06.006","article-title":"A case of safe and durable focal pulsed-field electroporation treatment of outflow tract premature ventricular contractions","volume":"4","author":"Worck","year":"2023","journal-title":"Heart Rhythm O2"},{"key":"2024073112210391500_euae192-B12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCEP.114.001530","article-title":"Complications of catheter ablation of ventricular tachycardia: a single-center experience","volume":"7","author":"Peichl","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112210391500_euae192-B13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jacep.2022.03.007","article-title":"Pulsed field ablation of left ventricular myocardium in a swine infarct model","volume":"8","author":"Im","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112210391500_euae192-B14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/europace\/euac252","article-title":"In vivo pulsed-field ablation in healthy vs. chronically infarcted ventricular myocardium: biophysical and histologic characterization","volume":"25","author":"Sandhu","year":"2023","journal-title":"Europace"},{"key":"2024073112210391500_euae192-B15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/medicina59040723","article-title":"Potential application of pulsed field ablation in ventricular arrhythmias","volume":"59","author":"Qiu","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"2024073112210391500_euae192-B16","doi-asserted-by":"crossref","first-page":"e012026","DOI":"10.1161\/CIRCEP.123.012026","article-title":"Effects of contact force on lesion size during pulsed field catheter ablation: histochemical characterization of ventricular lesion boundaries","volume":"17","author":"Nakagawa","year":"2024","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112210391500_euae192-B17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacep.2019.03.007","article-title":"Noninvasive programmed ventricular stimulation-guided management following ventricular tachycardia ablation","volume":"5","author":"Muser","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112210391500_euae192-B18","doi-asserted-by":"crossref","first-page":"e004202","DOI":"10.1161\/CIRCEP.116.004202","article-title":"Challenging radiofrequency catheter ablation of idiopathic ventricular arrhythmias originating from the left ventricular summit near the left main coronary artery","volume":"9","author":"Yamada","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024073112210391500_euae192-B19","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jacep.2020.07.023","article-title":"Intramural venous ethanol infusion for refractory ventricular arrhythmias: outcomes of a multicenter experience","volume":"6","author":"Tavares","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2024073112210391500_euae192-B20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ccep.2022.07.001","article-title":"Bipolar radiofrequency catheter ablation of left ventricular summit arrhythmias","volume":"15","author":"Futyma","year":"2023","journal-title":"Card Electrophysiol Clin"},{"key":"2024073112210391500_euae192-B21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s13239-022-00633-3","article-title":"Feasibility of linear irreversible electroporation ablation in the coronary sinus","volume":"14","author":"Buist","year":"2023","journal-title":"Cardiovasc Eng Technol"},{"key":"2024073112210391500_euae192-B22","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/CIRCULATIONAHA.122.061497","article-title":"Coronary arterial spasm during pulsed field ablation to treat atrial fibrillation","volume":"146","author":"Reddy","year":"2022","journal-title":"Circulation"},{"key":"2024073112210391500_euae192-B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.03.030","article-title":"Ablation of accessory pathways in different anatomic locations using focal pulsed field ablation","author":"Bre\u0161kovi\u0107","year":"2024","journal-title":"Heart Rhythm"},{"key":"2024073112210391500_euae192-B24","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.hrthm.2022.05.020","article-title":"Troponin release after pulmonary vein isolation using pulsed field ablation compared to radiofrequency and cryoballoon ablation","volume":"19","author":"Krisai","year":"2022","journal-title":"Heart Rhythm"},{"key":"2024073112210391500_euae192-B25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/jce.16157","article-title":"Myocardial injury and inflammation following pulsed-field ablation and very high-power short-duration ablation for atrial fibrillation","volume":"35","author":"Popa","year":"2024","journal-title":"J Cardiovasc Electrophysiol"}],"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euae192\/58500943\/euae192.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/26\/7\/euae192\/58616327\/euae192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/26\/7\/euae192\/58616327\/euae192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:59:47Z","timestamp":1722477587000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/doi\/10.1093\/europace\/euae192\/7710820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euae192","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,7]]},"article-number":"euae192"}}