{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:28:24Z","timestamp":1790447304045,"version":"4.1.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/ESP592"],"award-info":[{"award-number":["10.55776\/ESP592"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ILearnHeart Flagship","award":["I2760-B30"],"award-info":[{"award-number":["I2760-B30"]}]},{"name":"European Union\u2019s Horizon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Wolff\u2013Parkinson\u2013White (WPW) syndrome is a cardiovascular disease characterized by abnormal atrioventricular conduction facilitated by accessory pathways (APs). Invasive catheter ablation of the AP represents the primary treatment modality. Accurate localization of APs is crucial for successful ablation outcomes, but current diagnostic algorithms based on the 12-lead electrocardiogram (ECG) often struggle with precise determination of AP locations. In order to gain insight into the mechanisms underlying localization failures observed in current diagnostic algorithms, we employ a virtual cardiac model to elucidate the relationship between AP location and ECG morphology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We first introduce a cardiac model of electrophysiology that was specifically tailored to represent antegrade APs in the form of a short atrioventricular bypass tract. Locations of antegrade APs were then automatically swept across both ventricles in the virtual model to generate a synthetic ECG database consisting of 9271 signals. Regional grouping of antegrade APs revealed overarching morphological patterns originating from diverse cardiac regions. We then applied variance-based sensitivity analysis relying on polynomial chaos expansion on the ECG database to mathematically quantify how variation in AP location and timing relates to morphological variation in the 12-lead ECG. We utilized our mechanistic virtual model to showcase the limitations of AP localization using standard ECG-based algorithms and provide mechanistic explanations through exemplary simulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight the potential of virtual models of cardiac electrophysiology not only to deepen our understanding of the underlying mechanisms of WPW syndrome but also to potentially enhance the diagnostic accuracy of ECG-based algorithms and facilitate personalized treatment planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euae223","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T20:12:46Z","timestamp":1724875966000},"source":"Crossref","is-referenced-by-count":5,"title":["A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff\u2013Parkinson\u2013White syndrome"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-5375","authenticated-orcid":false,"given":"Karli","family":"Gillette","sequence":"first","affiliation":[{"name":"Division of Biophysics and Medical Physics, Gottfried Schatz Research Center, Medical University of Graz , Neue Stiftingtalstra\u00dfe 6, 8010 Graz ,","place":["Austria"]},{"name":"BioTechMed-Graz , Mozartgasse 12\/II, 8010 Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Winkler","sequence":"additional","affiliation":[{"name":"Physikalisch-Technische Bundesanstalt, National Metrology Institute , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-714X","authenticated-orcid":false,"given":"Stefan","family":"Kurath-Koller","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Medical University of Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-5493","authenticated-orcid":false,"given":"Daniel","family":"Scherr","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-3589","authenticated-orcid":false,"given":"Edward J","family":"Vigmond","sequence":"additional","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation University Bordeaux , Pessac-Bordeaux ,","place":["France"]},{"name":"Institute of Mathematics of Bordeaux, UMR 5251, University Bordeaux , Talence 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