{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:10:58Z","timestamp":1788117058829,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Norwegian Regional Health Authorities"},{"name":"Nasjonalt program for klinisk behandlingsforskning i spesialisthelsetjenesten","award":["22\/00793-5"],"award-info":[{"award-number":["22\/00793-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) is a common arrhythmia, and many cases of AF may be undiagnosed. Whether screening for AF and subsequent treatment if AF is detected can improve long-term outcome remains an unsettled question. The primary aim of the NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial is to assess whether self-screening for AF with continuous electrocardiogram (ECG) for 3\u20137 days in individuals aged 65 years or older with at least one additional risk factor for stroke, and initiation of guideline-recommended therapy in patients with detected AF, will reduce the occurrence of stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This study is a nationwide open, siteless, randomized, controlled trial. Individuals \u226565 years of age are randomly identified from the National Population Register of Norway and are invited to take a digital inclusion\/exclusion test. Individuals passing the inclusion\/exclusion test are randomized to either the intervention group or the control group. A total of 35 000 participants will be enrolled. In the intervention group, self-screening is performed continuously over 3\u20137 days at home with a patch ECG device (ECG247) at inclusion and after 12\u201318 months. If AF is detected, guideline-recommended therapy will be initiated. Patients will be followed up for 5 years through national health registries. The primary outcome is time to a first stroke (ischaemic or haemorrhagic stroke). The first participant in the NORSCREEN trial was enrolled on 1 September 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results from the NORSCREEN trial will provide new insights regarding the efficacy of digital siteless self-screening for AF with respect to stroke prevention in individuals at an increased risk of stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration<\/jats:title>\n                  <jats:p>Clinical trials: NCT05914883.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae228","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:31:49Z","timestamp":1725881509000},"source":"Crossref","is-referenced-by-count":7,"title":["The NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial: rationale and design of a randomized controlled trial"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2156-147X","authenticated-orcid":false,"given":"Miroslav","family":"Boskovic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Oslo , Oslo ,","place":["Norway"]},{"name":"Department of Cardiology, Sorlandet Hospital , Kristiansand ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-9852","authenticated-orcid":false,"given":"Jarle","family":"Jortveit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sorlandet Hospital , Arendal ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius Bl\u00f8rstad","family":"Haraldsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital Ullevaal , P.O. 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