{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:53:04Z","timestamp":1788897184343,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005884","name":"Centro Nacional de Investigaciones Cardiovasculares","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pro CNIC Foundation","award":["CEX2020-001041-S"],"award-info":[{"award-number":["CEX2020-001041-S"]}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["CB16\/11\/00458"],"award-info":[{"award-number":["CB16\/11\/00458"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heart Rhythm Association of the Spanish Society of Cardiology"},{"DOI":"10.13039\/501100023475","name":"Fundaci\u00f3n Interhospitalaria para la Investigaci\u00f3n Cardiovascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008055","name":"Fundaci\u00f3n Eugenio Rodr\u00edguez Pascual","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach on LGE-CMR images to identify VT corridors that contain critical VT isthmus sites.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This is a translational study including 18 pigs with established myocardial infarction and inducible VT undergoing in vivo characterization of the anatomical and functional myocardial substrate associated with VT maintenance. Clinical validation was conducted in a multicentre series of 33 patients with ischaemic cardiomyopathy undergoing VT ablation. Three-dimensional LGE-CMR images were processed using systematic scanning of 15 signal intensity (SI) cut-off ranges to obtain surface visualization of all potential VT corridors. Analysis and comparisons of imaging and electrophysiological data were performed in individuals with full electrophysiological characterization of the isthmus sites of at least one VT morphology. In both the experimental pig model and patients undergoing VT ablation, all the electrophysiologically defined isthmus sites (n = 11 and n = 19, respectively) showed overlapping regions with CMR-based potential VT corridors. Such imaging-based VT corridors were less specific than electrophysiologically guided ablation lesions at critical isthmus sites. However, an optimized strategy using the 7 most relevant SI cut-off ranges among patients showed an increase in specificity compared to using 15 SI cut-off ranges (70 vs. 62%, respectively), without diminishing the capability to detect VT isthmus sites (sensitivity 100%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Systematic imaging processing of LGE-CMR sequences using several SI cut-off ranges may improve and standardize procedure planning to identify VT isthmus sites.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euae244","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T18:59:36Z","timestamp":1726772376000},"source":"Crossref","is-referenced-by-count":8,"title":["Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-3325","authenticated-orcid":false,"given":"Alba","family":"Ramos-Prada","sequence":"first","affiliation":[{"name":"Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC) , Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid ,","place":["Spain"]},{"name":"Fundaci\u00f3n Interhospitalaria para la Investigaci\u00f3n Cardiovascular (FIC) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-0711","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Redondo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC) , Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-3731","authenticated-orcid":false,"given":"Ivo","family":"Roca-Luque","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Avenida Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029, Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital Cl\u00ednic , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-1488","authenticated-orcid":false,"given":"Andreu","family":"Porta-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Avenida Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029, Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital Cl\u00ednic , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-0132","authenticated-orcid":false,"given":"Rachel M A","family":"ter Bekke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-3507","authenticated-orcid":false,"given":"Jorge G","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC) , Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Avenida Monforte de Lemos, 3-5, Pabell\u00f3n 11, Planta 0, 28029, Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Cardiovascular Institute , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1427-3870","authenticated-orcid":false,"given":"Javier","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Philips Healthcare Iberia , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-0892","authenticated-orcid":false,"given":"Rafael","family":"Peinado","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario La Paz , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-1903","authenticated-orcid":false,"given":"Jose Luis","family":"Merino","sequence":"additional","affiliation":[{"name":"Cardiology 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