{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:50Z","timestamp":1792785890464,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MedLumics S.L"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Loss of bipolar electrograms immediately after pulsed field ablation (PFA) makes lesion durability assessment challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this trial (NCT 06700226) was to evaluate a novel ablation system that can optically predict lesion durability by detecting structural changes in the tissue during ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with paroxysmal atrial fibrillation underwent pulmonary vein isolation (PVI) using PFA (AblaView\u00ae, MedLumics). Using polarization-sensitive optical coherence reflectometry (PS-OCR), reflective characteristics of myocardial tissue and visualization of real-time contrast between healthy tissue and ablated tissue using a drop in tissue birefringence (BiR) was assessed. Wide antral PVI was performed using single point irrigated PFA (unipolar, 1800V, 3 trains, 21 s). Remapping was performed at 3 months. Primary efficacy outcome was the ability of PS-OCR to predict lesion durability at 3-month remapping. Serious adverse events were recorded. Ten patients were included. In total, 38\/40 PVs could be isolated with the system. The mean drop of BiR was 17.3 \u00b1 11.5%. Dragging across the ablation lines showed a persistent drop in BiR. During the remap procedures (8\/10 patients ablated only with PFA), 12 PVs (37.5%) were found to be electrically reconnected. The mean loss of BiR during all PFA for durable lesions was 20.9%, while only 10.1% BiR loss was observed during the index ablation for reconnected areas (P &amp;lt; 0.001). None of the points with \u226517% loss of birefringence was found to be reconnected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This first-in-human study supports the use of real-time drop in tissue BiR for lesion assessment and durability during PFA delivery, and its procedural safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euaf009","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:25:15Z","timestamp":1737095115000},"source":"Crossref","is-referenced-by-count":14,"title":["First-in-human trial of atrial fibrillation ablation using real-time tissue optical assessment to predict pulsed field lesion durability"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6712","authenticated-orcid":false,"given":"Raphael 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,","place":["Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-7740","authenticated-orcid":false,"given":"Sherzod","family":"Sabirov","sequence":"additional","affiliation":[{"name":"Cardiology Department, Ezgu Niyat Medical Center , Tashkent ,","place":["Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herranz","sequence":"additional","affiliation":[{"name":"Clinical Department, MedLumics , Tres Cantos, Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-1754","authenticated-orcid":false,"given":"Christophe","family":"Bailleul","sequence":"additional","affiliation":[{"name":"Clinical Department, MedLumics , Tres Cantos, Madrid 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