{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:29:26Z","timestamp":1789705766527,"version":"4.0.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000046","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>A dual-chamber leadless pacemaker (LP) system that employs distinct atrial and ventricular LP devices (ALP, VLP) has been introduced to clinical practice. Proprietary, low-energy, implant-to-implant (i2i) communication at each beat enables the devices to maintain synchronous atrioventricular sensing and pacing. We evaluated device longevities and contributing factors, such as i2i communication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients meeting dual-chamber pacing indications received the dual-chamber LP system as part of a prospective, multi-centre, international clinical trial (Aveir DR i2i Study, NCT05252702). Programming and diagnostics were interrogated from all de novo, non-revised, dual-chamber programmed devices at 12 months post-implant. This analysis included 302 patients (65% male; age 70 \u00b1 13 years; weight 80 \u00b1 19\u2005kg; intrinsic heart rate 55 \u00b1 7\u2005bpm; 58% sinus node dysfunction, 27% atrioventricular block). At 12 months, devices were programmed to dual-chamber pacing (DDD(R) or DDI(R)) at a median 60\u2005bpm rate, median 1.25\u2005V pulse amplitude in ALP and 1.5\u2005V in VLP, median 0.4\u2005ms pulse width, and median i2i signal setting level 5 out of 7. Median ALP and VLP remaining battery longevities at 12 months were 4.3 and 9.1 years, with median total ALP and VLP longevities of 5.3 and 9.9 years. Base rate, pulse amplitude, pacing percentage, event rate, impedance, and i2i setting level all exhibited significant correlations with ALP and VLP longevities (P &amp;lt; 0.001). Programming i2i setting levels below 7 produced the greatest longevity savings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The first dual-chamber LP demonstrated adequate projected battery longevity after 12 months of use. Patient-specific device programming considerations, unique to leadless devices, may extend longevity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf074","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T06:19:56Z","timestamp":1749190796000},"source":"Crossref","is-referenced-by-count":25,"title":["Battery longevity of a helix-fixation dual-chamber leadless pacemaker: results from the AVEIR DR i2i Study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-4993","authenticated-orcid":false,"given":"Vivek Y","family":"Reddy","sequence":"first","affiliation":[{"name":"Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, 1190 5th Ave, New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-7672","authenticated-orcid":false,"given":"Rahul","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology, HonorHealth Cardiac Arrhythmia Group , Scottsdale, AZ ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-505X","authenticated-orcid":false,"given":"James E","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Weill Cornell Medicine\/New York Presbyterian Hospital , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-4278","authenticated-orcid":false,"given":"Pascal","family":"Defaye","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, CHRU Albert Michallon , Grenoble ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek V","family":"Exner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, Foothills Medical Centre , Calgary ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Canby","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Texas Cardiac Arrhythmia Institute , Austin, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1772-6823","authenticated-orcid":false,"given":"Morio","family":"Shoda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women\u2019s Medical University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4755-1064","authenticated-orcid":false,"given":"Maria G","family":"Bongiorni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, San Rossore Private Hospital and Medical Center , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-0773","authenticated-orcid":false,"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center Leipzig GmbH , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-8165","authenticated-orcid":false,"given":"Petr","family":"Neu\u017eil","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Na Homolce Hospital , Prague ,","place":["Czech 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