{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:56:11Z","timestamp":1772171771731,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UCL BHF Research Accelerator","award":["AA\/18\/6\/34223"],"award-info":[{"award-number":["AA\/18\/6\/34223"]}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","award":["NIHR129463"],"award-info":[{"award-number":["NIHR129463"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","award":["UKRI\/ERC\/HORIZON 10103153"],"award-info":[{"award-number":["UKRI\/ERC\/HORIZON 10103153"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Despite several risk models to predict major arrhythmic events (MAE) in Brugada syndrome (BrS) having been developed, reproducibility and methodology remain a concern. Our aim was to assess the quality of model development and validation, and determine the discriminative performance of available models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Electronic databases (Medline, Embase, and Central) were searched through September\/2024 for studies developing or validating multivariable prediction models for MAE in BrS. Methodological quality and risk of bias (RoB) were assessed using the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS) checklist and the Prediction Model Risk of Bias Assessment (PROBAST) Tool. Pooled random-effects c-statistics were obtained for each model. A total of 16 studies, including 11 unique multivariable scores, were included. All models had domains classified as high RoB. Common sources of bias were inappropriate inclusion\/exclusion criteria, predictor selection, low number of events and underreporting of performance measures. Pooled c-statistics among patients without previous MAE showed good performance for Brugada-Risk [AUC 0.81, 95% confidence interval (CI) 0.71\u20130.91; I2 64%; three studies], fair for PAT (AUC 0.79, 95% CI 0.45\u20131.12; I2 95%; two studies), Delise (AUC 0.77, 95% CI 0.72\u20130.81, I2 39%, three studies), and Sieira (AUC 0.73, 95% CI 0.64\u20130.82; I2 64%; five studies), and moderate for Shanghai (AUC 0.69, 95% CI 0.61\u20130,76; I2 13%; three studies).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Currently available multiparametric models for prediction of MAE in BrS have important shortcomings in model development and inadequate evaluation. Further validation of current models in external cohorts is required before safe transition to clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf091","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:13:06Z","timestamp":1746180786000},"source":"Crossref","is-referenced-by-count":5,"title":["Multiparametric models for predicting major arrhythmic events in Brugada syndrome: a systematic review and critical appraisal"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-648X","authenticated-orcid":false,"given":"Daniel A","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital de Santa Cruz , Lisbon ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-9267","authenticated-orcid":false,"given":"Pier D","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London , London ,","place":["UK"]},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-8241","authenticated-orcid":false,"given":"Richard J","family":"Schilling","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , London ,","place":["UK"]},{"name":"William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-9525","authenticated-orcid":false,"given":"Riccardo","family":"Cappato","sequence":"additional","affiliation":[{"name":"Arrhythmia and Clinical Electrophysiology 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