{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:34:36Z","timestamp":1790613276416,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Very high-power short-duration (vHPSD) was developed to optimize radiofrequency ablation for atrial fibrillation (AF). However, data on vHPSD \u2265 70W remains limited. We investigated acute efficacy, safety and long-term rhythm outcomes of vHPSD-70W in a randomized controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of n = 200 patients with paroxysmal AF were randomly assigned 1:1 to receive pulmonary vein isolation (PVI) using vHPSD (70 W\/5\u20137\u2005s) or standard (30\u201340W, 20\u201340\u2005s) ablation with a flexible, enhanced-irrigation tip catheter. Primary endpoint was the number of reconnected pulmonary veins (rPV) after adenosine testing. Secondary endpoints included first-pass isolation (FPI), silent cerebral lesions (SCLs) and rhythm outcomes on 12-month follow-up. Mean number of rPVs was 0.6 \u00b1 0.8 vs. 0.8 \u00b1 0.9 (P = 0.145) with vHPSD-70W vs. standard ablation. Bilateral FPI was 42.7% vs. 30.2% (P = 0.072), while FPI of left PVs was higher with vHPSD-70W (63.5% vs. 49.0%, P = 0.042). Procedure (107.7 \u00b1 34.2 vs. 131.3 \u00b1 42.2\u2005min) and radiofrequency (15.1 \u00b1 6.7 vs. 41.8 \u00b1 18.3\u2005min) duration were significantly lower with vHPSD-70W (P &amp;lt; 0.001). Silent cerebral lesions occurred in 1\/25 (4.0%) vs. 3\/22 (13.6%, P = 0.328). On 12-month follow-up, freedom from any atrial arrhythmia (76.0% vs. 66.7%, P = 0.171) was similar, while vHPSD-70W showed a lower incidence of atrial tachycardia (AT) recurrence (1.0% vs. 10.4%, P = 0.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Very high-power short-duration with 70\u2005W\/5\u20137\u2005s was non-superior to standard ablation regarding acute PV reconnection and 12-month freedom from any atrial arrhythmia. However, vHPSD-70W achieved a higher FPI rate of left PVs with a shorter procedure duration and a comparable safety profile. AT recurrence was significantly less common with vHPSD-70W.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf105","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:54:28Z","timestamp":1753102468000},"source":"Crossref","is-referenced-by-count":3,"title":["Very high-power short-duration using 70W and a flexible tip ablation catheter for pulmonary vein isolation: the POWER PULSE randomized controlled trial"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-2492","authenticated-orcid":false,"given":"Miruna A","family":"Popa","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-7545","authenticated-orcid":false,"given":"Hannah","family":"Krafft","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-5403","authenticated-orcid":false,"given":"Fabian","family":"Bahlke","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-4190","authenticated-orcid":false,"given":"Florian","family":"Englert","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lengauer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Telishevska","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Erhard","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Tydecks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hadamitzky","sequence":"additional","affiliation":[{"name":"Institute for Radiology and Nuclear Medicine, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-6595","authenticated-orcid":false,"given":"Felix","family":"Bourier","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-0359","authenticated-orcid":false,"given":"Tilko","family":"Reents","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Klupp","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum Rechts der Isar, Technical University of Munich , Ismaninger Str. 22, Munich 81675 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-6474","authenticated-orcid":false,"given":"Carsten","family":"Lennerz","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Hessling","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6846","authenticated-orcid":false,"given":"Isabel","family":"Deisenhofer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich, Technical University of Munich , Lazarettstra\u00dfe 36, Munich 80636 ,","place":["Germany"]},{"name":"Munich Arrhythmia Research and Study Center (MARS) , Technical University of Munich, Lazarettstra\u00dfe 36, Munich 80636 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